CAJ | 학술논문

目的：回顾性分析原发性醛固酮增多症(PA)的临床诊治资料，为 PA 的临床诊治提供参考。方法选取确诊为 PA 的患者25例，归纳分析患者的临床表现、生化检查结果、影像学检查结果、靶器官损害情况及治疗和预后等。结果女性患者年龄、血钾水平均高于男性患者(P<0.05)；女性患者体重指数(BMI)舒张压及血钠水平均低于男性患者(P<0.05)。 CT 检查确诊肾上腺病变阳性为96.0%， MRI 为92.0%，与病理诊断阳性率的92.0%基本相符。患者均出现了不同程度的靶器官损害，以颈部动脉粥样硬化斑块形成程度最大，共20例(80.0%)。25例患者均接受了手术治疗，且术后1 w 血压正常者达到15例(60.0%)，血钾正常者达到20例(80.0%)。结论科学诊治并及早行手术治疗，可有效改善患者的临床症状，改善患者的预后，具有重要的临床价值。
목적：회고성분석원발성철고동증다증(PA)적림상진치자료，위 PA 적림상진치제공삼고。방법선취학진위 PA 적환자25례，귀납분석환자적림상표현、생화검사결과、영상학검사결과、파기관손해정황급치료화예후등。결과녀성환자년령、혈갑수평균고우남성환자(P<0.05)；녀성환자체중지수(BMI)서장압급혈납수평균저우남성환자(P<0.05)。 CT 검사학진신상선병변양성위96.0%， MRI 위92.0%，여병리진단양성솔적92.0%기본상부。환자균출현료불동정도적파기관손해，이경부동맥죽양경화반괴형성정도최대，공20례(80.0%)。25례환자균접수료수술치료，차술후1 w 혈압정상자체도15례(60.0%)，혈갑정상자체도20례(80.0%)。결론과학진치병급조행수술치료，가유효개선환자적림상증상，개선환자적예후，구유중요적림상개치。
Objective To provide reference for the clinical diagnosis of PA from retrospectively analyzing the clinical data of pri-mary aldosteronism (PA). Methods 25 patients diagnosed with PA were selected and their clinical performance, biochemical test re-sults, imaging findings, the damage, treatment and prognosis of the target organ were analyzed inductively. Results The age and ser-um potassium levels of female patients were higher than those of male patients (P<0. 05). The BMI and diastolic blood sodium levels of women were lower than those of the male patients (P<0. 05). There were 96. 0% positive adrenal lesions of CT and 92. 0% MRI, which was basically in line with the rate of positive pathologic diagnosis (92. 0% ). Patients experienced various degrees of target organ damage, among which, the extent of damage of the carotid artery atherosclerotic plaque formation was maximum (80. 0% ), altogether 20 cases. 25 patients all underwent surgery, and after one week of the treatment, the number of normotensives was 15 cases (60. 0% ), with 20 cases of normal serum potassium (80. 0% ). Conclusion Scientific diagnosis and early operation for PA can ef-fectively improve the clinical symptoms and the prognosis of the patients, which prove to be clinically valuable.