CAJ | 학술논문

目的：探讨非小细胞肺癌（ NSCLC）骨转移患者骨相关事件（ SREs）的发生，并分析患者的预后因素。方法回顾性分析我科诊治的118例NSCLC骨转移患者SREs的发生率，并分析各预后相关危险因素，单因素分析应用Kaplan-Meier法，多因素分析应用Cox回归模型。结果118例患者中，44例（37.3%）在初诊为骨转移时即发生SREs，118例患者中位生存时间为13（11.11~14.89）个月，单因素分析显示，病理类型、骨转移灶数目、PS评分、诊断骨转移时是否发生SREs、是否给予靶向治疗与预后有关；而多因素分析则显示病理类型、骨转移灶数目、PS评分、是否给予靶向治疗是影响预后的独立因素。结论在发生SREs的NSCLC骨转移患者中，对腺癌、单发骨转移灶、PS评分为0~1分的患者给予更积极的治疗，有可能使这部分患者生存受益。
목적：탐토비소세포폐암（ NSCLC）골전이환자골상관사건（ SREs）적발생，병분석환자적예후인소。방법회고성분석아과진치적118례NSCLC골전이환자SREs적발생솔，병분석각예후상관위험인소，단인소분석응용Kaplan-Meier법，다인소분석응용Cox회귀모형。결과118례환자중，44례（37.3%）재초진위골전이시즉발생SREs，118례환자중위생존시간위13（11.11~14.89）개월，단인소분석현시，병리류형、골전이조수목、PS평분、진단골전이시시부발생SREs、시부급여파향치료여예후유관；이다인소분석칙현시병리류형、골전이조수목、PS평분、시부급여파향치료시영향예후적독립인소。결론재발생SREs적NSCLC골전이환자중，대선암、단발골전이조、PS평분위0~1분적환자급여경적겁적치료，유가능사저부분환자생존수익。
Objective Toinvestigatetheskeletalrelatedevents(SREs)andtheprognosticfactorsofnon-small-celllungcancer(NSCLC)patientswithbonemetastasis.Methods OnehundredandeighthNSCLCpatientswith SREs were investigated retrospectively. The frequency of SREs and the prognostic factors were analyzed. Results Ofthe118patients,44experiencedSREsattheinitialdiagnosisofNSCLCwithbonemetastasis.Themediansur-vival time was 13(11. 11-14. 89)months for the 118 patients. The univariate analysis showed that the significant prognostic factors included tumor subtype,number of skeletal metastases,PS score,SREs at the initial diagnosis of NSCLC with bone metastasis and target therapy. The multivariate analysis indicated that tumor subtype,number of skeletalmetastases,PSscoreandtargettherapywereindependentprognosticfactors.Conclusion FortheNSCLC patients with bone metastasis,the patients with adenocarcinoma,single bone metastasis,good PS score are treated more positively,their mean survival may be longer.