CAJ | 학술논문

目的：观察全身热疗联合DCF方案化疗治疗晚期胃癌的近期疗效及毒副反应。方法67例晚期胃癌患者随机分为治疗组（32例）和对照组（35例），2组患者均采用DCF方案全身化疗，化疗第1天在全麻状态下用ET-SPACE全身热疗系统进行全身加热时开始静脉给药。结果治疗组总有效率和生活质量提高率均高于对照组（P均<0.05）；2组毒副反应发生率比较差异无统计学意义（P均>0.05）。结论全身热疗联合DCF方案化疗治疗晚期胃癌可以获得较好的近期疗效，改善患者的生活质量，且毒副反应未增加，值得临床进一步推广。
목적：관찰전신열료연합DCF방안화료치료만기위암적근기료효급독부반응。방법67례만기위암환자수궤분위치료조（32례）화대조조（35례），2조환자균채용DCF방안전신화료，화료제1천재전마상태하용ET-SPACE전신열료계통진행전신가열시개시정맥급약。결과치료조총유효솔화생활질량제고솔균고우대조조（P균<0.05）；2조독부반응발생솔비교차이무통계학의의（P균>0.05）。결론전신열료연합DCF방안화료치료만기위암가이획득교호적근기료효，개선환자적생활질량，차독부반응미증가，치득림상진일보추엄。
Objective ToobservetheeffectandtoxicitiesofwholebodyhyperthermiacombinedwithDCFregi-menchemotherapyinthetreatmentofpatientswithadvancedgastriccancer.Methods Sixty-sevenpatientswith advanced gastric cancer were randomly divided into two groups. Thirty-two patients of the treatment group was trea-ted by DCF regimen combining with whole body hyperthermia on the first day,and 35 patients of the control group wastreatedwithDCFregimenalone.Results Theresponserateandqualityoflifeinthetreatmentgroupwerebet-ter than those in the control group(P<0. 05). There was no statistical difference in the toxicities between the two groups(P>0.05).Conclusion WholebodyhyperthermiacanenhancetheeffectofDCFregimenchemotherapy for patients with advanced gastric cancer,improve the quality of life,do not increase the toxicities of chemotherapy.