CAJ | 학술논문

目的：探讨VTLP方案治疗初治成人急性淋巴细胞白血病的临床疗效。方法98例成人初治急性淋巴细胞白血病患者分为2组，每组49例，VDLP方案组行VDLP方案诱导化疗，VTLP方案组行VTLP方案诱导化疗。结果2组化疗后的完全缓解率比较差异无统计学意义（P>0.05）；VTLP方案组骨髓抑制程度、继发感染率及复发率均低于VDLP方案组（ P<0.05）。结论与VTLP方案治疗初治成人急性淋巴细胞白血病高效低毒，可作为成人初治急性淋巴细胞白血病的诱导化疗方案。
목적：탐토VTLP방안치료초치성인급성림파세포백혈병적림상료효。방법98례성인초치급성림파세포백혈병환자분위2조，매조49례，VDLP방안조행VDLP방안유도화료，VTLP방안조행VTLP방안유도화료。결과2조화료후적완전완해솔비교차이무통계학의의（P>0.05）；VTLP방안조골수억제정도、계발감염솔급복발솔균저우VDLP방안조（ P<0.05）。결론여VTLP방안치료초치성인급성림파세포백혈병고효저독，가작위성인초치급성림파세포백혈병적유도화료방안。
Objective ToinvestigatetheclinicaleffectsofVTLPregimeninthetreatmentofnewlydiagnoseda-dultacutelymphoblasticleukemia.Methods Ninety-eightcasesofnewlydiagnosedadultacutelymphoblasticleu-kemia were randomly divided into two groups,49 cases of the VDLP regimen group received VDLP regimen induc-tion chemotherapy,and 49 cases of the VTLP regimen group received VTLP regimen induction chemotherapy. Re-sults Therewasnostatisticaldifferenceinthecompleteremissionratebetweenthetwogroups(P>0.05).The bone marrow suppression degree,secondary infection rate and recurrence rate in the VTLP regimen group were low-erthanthoseintheVDLPregimengroup(P<0.01).Conclusion VTLPregimencanbeusedasaprimarytreat-ment of adult acute lymphoblastic leukemia.