肿瘤基础与临床
腫瘤基礎與臨床
종류기출여림상
JOURNAL OF BASIC AND CLINICAL ONCOLOGY
2014年
5期
369-373
,共5页
张惠娟%张朋%赵学科%宋昕%黄佳%袁果%姬玲粉%张唐娟%吴敏杰%殷言言%胡守佳%吕双%李健%王立东
張惠娟%張朋%趙學科%宋昕%黃佳%袁果%姬玲粉%張唐娟%吳敏傑%慇言言%鬍守佳%呂雙%李健%王立東
장혜연%장붕%조학과%송흔%황가%원과%희령분%장당연%오민걸%은언언%호수가%려쌍%리건%왕립동
食管鳞癌%分化程度%淋巴结转移%年龄%性别
食管鱗癌%分化程度%淋巴結轉移%年齡%性彆
식관린암%분화정도%림파결전이%년령%성별
esophageal squamous cell carcinoma%degree of differentiation%lymph node metastasis%age%gender
目的：分析食管癌高低发区食管鳞癌患者分化程度与淋巴结转移的关系。方法14335例食管鳞癌患者临床病理信息均来自河南省食管癌重点开放实验室食管癌资料库，其中高发区7007例、低发区7328例；所有患者均经手术治疗，并详细记录患者术后病理，包括分化程度和淋巴结转移等。结果高发区和低发区食管鳞癌患者均以中分化为主（48% vs 61%），低分化和高分化次之，未分化最少（0.6% vs 0.4%）。高发区男性患者40~49岁和50~59岁年龄组高分化率明显高于同年龄组低发区患者（ P <0.05）；但高发区女性患者仅40~49岁年龄组高分化率明显高于同年龄组低发区患者（ P<0.05）。特别值得指出的是：高发区（ r=0.125，P<0.05）和低发区（ r=0.105，P<0.05）患者分化程度与淋巴结转移显著相关。结论高低发区食管鳞癌患者均以中分化为主；高发区男性和女性40~49岁年龄组高分化率均明显高于同年龄组低发区患者；分化程度与淋巴结转移关系密切，分化程度越差，淋巴结转移阳性率越高。
目的：分析食管癌高低髮區食管鱗癌患者分化程度與淋巴結轉移的關繫。方法14335例食管鱗癌患者臨床病理信息均來自河南省食管癌重點開放實驗室食管癌資料庫，其中高髮區7007例、低髮區7328例；所有患者均經手術治療，併詳細記錄患者術後病理，包括分化程度和淋巴結轉移等。結果高髮區和低髮區食管鱗癌患者均以中分化為主（48% vs 61%），低分化和高分化次之，未分化最少（0.6% vs 0.4%）。高髮區男性患者40~49歲和50~59歲年齡組高分化率明顯高于同年齡組低髮區患者（ P <0.05）；但高髮區女性患者僅40~49歲年齡組高分化率明顯高于同年齡組低髮區患者（ P<0.05）。特彆值得指齣的是：高髮區（ r=0.125，P<0.05）和低髮區（ r=0.105，P<0.05）患者分化程度與淋巴結轉移顯著相關。結論高低髮區食管鱗癌患者均以中分化為主；高髮區男性和女性40~49歲年齡組高分化率均明顯高于同年齡組低髮區患者；分化程度與淋巴結轉移關繫密切，分化程度越差，淋巴結轉移暘性率越高。
목적：분석식관암고저발구식관린암환자분화정도여림파결전이적관계。방법14335례식관린암환자림상병리신식균래자하남성식관암중점개방실험실식관암자료고，기중고발구7007례、저발구7328례；소유환자균경수술치료，병상세기록환자술후병리，포괄분화정도화림파결전이등。결과고발구화저발구식관린암환자균이중분화위주（48% vs 61%），저분화화고분화차지，미분화최소（0.6% vs 0.4%）。고발구남성환자40~49세화50~59세년령조고분화솔명현고우동년령조저발구환자（ P <0.05）；단고발구녀성환자부40~49세년령조고분화솔명현고우동년령조저발구환자（ P<0.05）。특별치득지출적시：고발구（ r=0.125，P<0.05）화저발구（ r=0.105，P<0.05）환자분화정도여림파결전이현저상관。결론고저발구식관린암환자균이중분화위주；고발구남성화녀성40~49세년령조고분화솔균명현고우동년령조저발구환자；분화정도여림파결전이관계밀절，분화정도월차，림파결전이양성솔월고。
Objective Tocorrelatethedifferentiationandlymphnodemetastasisinthepatientswithesophageal squamouscellcarcinomafromthehigh-andthelow-incidenceareasforesophagealcarcinoma.Methods Allthe clinical and pathological information from the 14 335 patients with esophageal squamous cell carcinoma were derived from the esophageal carcinoma biobank in Henan Key Laboratory for Esophageal Cancer Research. Of all the pa-tients,7 007 patients were from the high-incidence area for esophageal carcinoma and 7 328 from the low-incidence area for esophageal carcinoma. All the patients were performed surgical treatment. The detailed information,including differentiationandlymphnodemetastasiswererecorded.Results Predominantly,themiddledifferentiationwasthe common type for the patients with esophageal squamous cell carcinoma from both the high-and low-incidence areas for esophageal carcinoma(48% vs 61%),followed by the lower and high differentiation,the undifferentiation was very rare type for esophageal squamous cell carcinoma both in the high-and low-incidence areas for esophageal car-cinoma(0. 6% vs 0. 4%). The male patients with the age groups of 40-49 and 50-59 from the high-incidence area had the higher rate of high differentiation than those from the low-incidence area(P<0. 05);furthermore,in the fe-male patients,only those with the age group of 40-49 from the high-incidence area had higher rate of high differentia-tion than those from the low-incidence area(P<0. 05). It was noteworthy that cancer cell differentiation was corre-lated apparently with lymph node metastasis both in the high-(r =0. 125,P <0. 05)and low-incidence(r =0. 105,P<0. 05)areas for esophageal carcinoma. The poor the differentiation was,the higher the rate for lymph nodemetastasis(P<0.05).Conclusion Middledifferentiationisthepredominanttypeforthepatientswith esophageal squamous cell carcinoma from both the high-and low-incidence areas for esophageal carcinoma;both the male and the female at the age group of 40-49 from the high-incidence area for esophageal carcinoma has a higher rate of high differentiation than those from the low-incidence area for esophageal carcinoma;differentiation is closely correlated with lymph node metastasis,the poorer the differentiation,the higher the rate of lymph node metastasis.
