CAJ | 학술논문

目的：通过对广西耐药结核病可疑者筛查结果分析，了解可疑者耐药、耐多药疫情现状与特点。方法采用回顾性调查方法，对2012年1月至2014年6月期间结核病管理信息系统登记的耐药结核病可疑者筛查资料进行统计分析。结果共有657例患者有菌种鉴定和药敏试验结果，主要分布在南宁、柳州、桂林、梧州、北海、贵港和贺州等7个市。非结核分枝杆菌感染占患者总数的5.0%（33/657），而在新患者中占3.4%（12/348），在复治患者中占6.8%（21/309）。新患者总耐药率为19.6%（66/336），复治患者总耐药率为56.3%（162/288）；新患者耐多药率为7.7%（26/336），复治患者耐多药率为41.3%（119/288），广泛耐多药率0.7%（2/288）。桂林市复治患者单耐利福平（RMR-TB）率高达18.8%（6/32）。结论广西结核病耐药可疑者耐药率、耐多药率高，个别市RMR-TB率、非结核分枝杆菌感染率高，应引起重视。
목적：통과대엄서내약결핵병가의자사사결과분석，료해가의자내약、내다약역정현상여특점。방법채용회고성조사방법，대2012년1월지2014년6월기간결핵병관리신식계통등기적내약결핵병가의자사사자료진행통계분석。결과공유657례환자유균충감정화약민시험결과，주요분포재남저、류주、계림、오주、북해、귀항화하주등7개시。비결핵분지간균감염점환자총수적5.0%（33/657），이재신환자중점3.4%（12/348），재복치환자중점6.8%（21/309）。신환자총내약솔위19.6%（66/336），복치환자총내약솔위56.3%（162/288）；신환자내다약솔위7.7%（26/336），복치환자내다약솔위41.3%（119/288），엄범내다약솔0.7%（2/288）。계림시복치환자단내리복평（RMR-TB）솔고체18.8%（6/32）。결론엄서결핵병내약가의자내약솔、내다약솔고，개별시RMR-TB솔、비결핵분지간균감염솔고，응인기중시。
Objective To determine the prevalence of the drug resistant tuberculosis among antibiotic resistant suspects in Guangxi. Methods A retrospective survey was conducted to collect surveillance data on TB patients who were suspicious to anti-TB drug resistance. All data was derived from National Tuberculosis Management Information System on TB patients who were suspicious to resisting anti-TB drug, from January 2012 to June 2014 in Guangxi. Results Among 657 suspects from 7 cities of Nanning, Liuzhou, Guilin, Wuzhou, Beihai, Guigang and Hezhou, 3.4 % (12/348) of the new cases and 6.8% (21/309) of the retreated cases were identified as nontuberculosis Mycobacteria (NTM) infection respectively. Drug sensitive test showed that 19.6% (66/336) of the new cases and 56.3%(162/288) of the retreated cases were any drug resistant, 7.7%(26/336) of new cases and 41.3%(119/288) of the retreated cases were MDR-TB. Furthermore,18.8%(6/32)of the retreated cases from Guilin were rifampin-monoresistant (RMR). Conclusion It should be paid attention to high prevalence of anti-TB drug resistance especially MDR, RMR and NTM among TB patients who are suspicious to anti-TB drug resistance in Guangxi.