CAJ | 학술논문

以异丙基丙烯酰胺(NIPAAm)和羟甲基丙烯酰胺(NHMAm)为共聚单体与壳聚糖(CS)制备形成了温度敏感和pH敏感的互穿网络(IPN)水凝胶 Poly(NIPAAm-co-NHMAm)/CS；用红外光谱表征了其结构特征，研究了不同条件下水凝胶的溶胀性能，并初步研究了水凝胶对药物双氯芬酸钠(DS)的缓释效果。结果表明，该水凝胶具有明显的温度和 pH敏感性，温度越高，溶胀度越小，释药越慢；pH越小，溶胀度越大；CS含量为0.6%时溶胀度最大。在NHMAm单体质量配比为8.7%时，水凝胶的低临界溶液温度(LCST)达到38℃，且此时对DS持续释药时间可达到24 h。水凝胶的释药动力学曲线符合修正的一级动力学模型。该水凝胶体系可通过改变NHMAm单体配比来调节温敏特性，是一种潜在的温度和pH双重敏感的药物缓释载体。
이이병기병희선알(NIPAAm)화간갑기병희선알(NHMAm)위공취단체여각취당(CS)제비형성료온도민감화pH민감적호천망락(IPN)수응효 Poly(NIPAAm-co-NHMAm)/CS；용홍외광보표정료기결구특정，연구료불동조건하수응효적용창성능，병초보연구료수응효대약물쌍록분산납(DS)적완석효과。결과표명，해수응효구유명현적온도화 pH민감성，온도월고，용창도월소，석약월만；pH월소，용창도월대；CS함량위0.6%시용창도최대。재NHMAm단체질량배비위8.7%시，수응효적저림계용액온도(LCST)체도38℃，차차시대DS지속석약시간가체도24 h。수응효적석약동역학곡선부합수정적일급동역학모형。해수응효체계가통과개변NHMAm단체배비래조절온민특성，시일충잠재적온도화pH쌍중민감적약물완석재체。
A thermosensitive and pH-sensitive interpenetrating polymeric networks (IPN) hydrogel was synthesized by polymerization of N-isopropylacrylaimde (nipaaM) and N-hydroxymethyl acrylamide(NHMAm) in the presence of chitosan (CS). The chemical structure of the hydrogel was determined by IR spectra, and the swelling ratio of hydrogel and its releasing property for diclofenac sodium (DS) were investigated. It was found that the IPN hydrogel exhibits typical thermo-sensitivity and pH-sensitivity. Its swelling ratio and releasing rate decreases as the increase of temperature. The swelling ratio increases with the decreased pH. When CS content is 0.6%, the swelling ratio reaches its maximum. With the increase of NHMAm mass ratio,the swelling ratio and the LCST (low critical solution temperature) of hydrogel increases. When NHMAm mass ratio is 8.7%, LCST is 38℃ and sustained drug releasing time lasts 24 h. The drug release behavior follows a modified first order model. The results suggest that the poly(NIPAAm-co-NHMAm)/CS hydrogel is a potential thermo-sensitivity and pH-sensitivity carrier for controlled drug release.