西北药学杂志
西北藥學雜誌
서북약학잡지
2014年
6期
650-652
,共3页
喜炎平注射液%不良反应%中药注射剂
喜炎平註射液%不良反應%中藥註射劑
희염평주사액%불량반응%중약주사제
Xiyanping Injections%adverse drug reaction%Chinese medicinal injection
目的：分析喜炎平注射液所致不良反应的特点和原因，为临床安全用药提供参考。方法检索国内1994年1月～2013年6月应用喜炎平注射液出现的不良反应报道，从患者性别与年龄分布、既往过敏史、不良反应发生时间、累及器官或系统等方面进行整理、分析。结果喜炎平注射液所致不良反应相关文献共36篇，有效病例41例。喜炎平注射液引起的不良反应性别差异不明显，在各年龄段均有分布。不良反应多数发生在用药后30 min 内，且多为多系统损害，其主要症状为胸闷、心悸、呼吸困难、面色苍白、意识模糊、血压急剧下降、咳嗽、皮肤瘙痒、斑丘疹、荨麻疹等。过敏性休克发生率39．02％（16/41），死亡1例。结论引起喜炎平注射液不良反应的因素较多，机制较复杂。临床医师、药师、护士及药品生产企业都应重视喜炎平注射液的不良反应。
目的：分析喜炎平註射液所緻不良反應的特點和原因，為臨床安全用藥提供參攷。方法檢索國內1994年1月～2013年6月應用喜炎平註射液齣現的不良反應報道，從患者性彆與年齡分佈、既往過敏史、不良反應髮生時間、纍及器官或繫統等方麵進行整理、分析。結果喜炎平註射液所緻不良反應相關文獻共36篇，有效病例41例。喜炎平註射液引起的不良反應性彆差異不明顯，在各年齡段均有分佈。不良反應多數髮生在用藥後30 min 內，且多為多繫統損害，其主要癥狀為胸悶、心悸、呼吸睏難、麵色蒼白、意識模糊、血壓急劇下降、咳嗽、皮膚瘙癢、斑丘疹、蕁痳疹等。過敏性休剋髮生率39．02％（16/41），死亡1例。結論引起喜炎平註射液不良反應的因素較多，機製較複雜。臨床醫師、藥師、護士及藥品生產企業都應重視喜炎平註射液的不良反應。
목적：분석희염평주사액소치불량반응적특점화원인，위림상안전용약제공삼고。방법검색국내1994년1월～2013년6월응용희염평주사액출현적불량반응보도，종환자성별여년령분포、기왕과민사、불량반응발생시간、루급기관혹계통등방면진행정리、분석。결과희염평주사액소치불량반응상관문헌공36편，유효병례41례。희염평주사액인기적불량반응성별차이불명현，재각년령단균유분포。불량반응다수발생재용약후30 min 내，차다위다계통손해，기주요증상위흉민、심계、호흡곤난、면색창백、의식모호、혈압급극하강、해수、피부소양、반구진、담마진등。과민성휴극발생솔39．02％（16/41），사망1례。결론인기희염평주사액불량반응적인소교다，궤제교복잡。림상의사、약사、호사급약품생산기업도응중시희염평주사액적불량반응。
Objective To analyze the status and characteristics of adverce drug reactions associated with Xiyanping Injections for ra-tional administration in clinic .Methods The domestic reports on adverce drug reactions caused by Xiyanping Injections from Janu-ary 1994 to June 2013 were retrieved .And the distribution of gender and age ,occurrence time of adverce drug reactions ,adverce drug reactions history of patients ,the primary diseases ,utilization of drugs ,organs or systems involved in adverce drug reactions and main clinical manifestations ,rescuing measures and prognosis were analyzed .Results There were 41 cases of adverce drug re-action caused by Xiyanping Injections published in 36 papers ,which had no obvious significance in gender and age .32 cases oc-curred in thirty minutes after administration ,which accounted for 94 .1% .The main clinical symptoms on adverce drug reaction included tachypnea ,chest tightness ,pale complexion ,no blood pressure ,mental confusion ,cough ,itch of skin ,maculopapule , urticaria and others .The allergic shock was common in all ADRs of Xiyanping Injections .Among 41 cases ,16 were an aphylactic shock (accounting for 39 .02% ) ,1 case was dead due to aphylactic reaction .Conclusion The adverce drug reaction caused by Xiy-anping Injections was related to lots of factors .The mechanism is complex .Clinical doctors ,pharmacist ,nurse and drug manu-facturer should pay attention to adverce drug reaction associated with Xiyanping Injections .
