CAJ | 학술논문

目的：以丙烯酸树脂为膜材制备载药蒙脱石/丙烯酸树脂微球并考察其体外释放性能。方法以盐酸倍他洛尔为模型药物，采用 O/O 溶剂挥发法制备蒙脱石载药微球，通过正交实验设计，考察柠檬酸三乙酯及甘油用量、乳化剂与膜材比例及用量、内外相体积比等因素对微球载药量、包封率、体外释放性能的影响，采用扫描电镜对其外观形态进行表征。结果所得微球外观圆整，粒径分布较均匀，平均粒径为20．7μm ，平均载药量为14．31％±0．47％，平均包封率为94．35％±1．01％。结论该法制备载药蒙脱石丙烯酸树脂微球是可行的，体外释放研究表明微球具有一定的缓释作用。
목적：이병희산수지위막재제비재약몽탈석/병희산수지미구병고찰기체외석방성능。방법이염산배타락이위모형약물，채용 O/O 용제휘발법제비몽탈석재약미구，통과정교실험설계，고찰저몽산삼을지급감유용량、유화제여막재비례급용량、내외상체적비등인소대미구재약량、포봉솔、체외석방성능적영향，채용소묘전경대기외관형태진행표정。결과소득미구외관원정，립경분포교균균，평균립경위20．7μm ，평균재약량위14．31％±0．47％，평균포봉솔위94．35％±1．01％。결론해법제비재약몽탈석병희산수지미구시가행적，체외석방연구표명미구구유일정적완석작용。
Objective The purpose of this study was to prepare drug-loaded montmorillonite-eudragit composite microspheres with eudragit as the membrane material and study its release in vitro .Methods Betaxolol hydrochloride was used as a model drug .The microspheres were prepared by oil in oil solvent evaporation technique .An orthogonal experimental design was used to study the effect of the amount of triethyl citrate and glycerol ,the ratio and amount of emulsifier and membrane material ,the volume ratio of internal oil phase and external oil phase on microspheres .Drug loading capacity and encapsulation efficiency were used as evalua-ting indicators .The morphology of microparticle was characterized by SEM .Results The microspheres were spherical in the shape ,and the size distribution was uniform .The mean particle size was 20 .7 μm .The average drug loading capacity and the en-capsulation efficiency were 14 .31% ± 0 .47% and 94 .35% ± 1 .01% ,respectively .Conclusion The method for the preparation of drug-loaded montmorillonite-eudragit composite microspheres is feasible ,while the in vitro release study of microspheres showed that the drug was sustainedly released .