CAJ | 학술논문

目的：观察紫冰霜对动物皮肤的毒性作用及体外抑菌作用。方法采用健康家兔进行皮肤急性毒性实验和皮肤刺激性实验；采用豚鼠进行皮肤致敏性实验；采用纸片法进行体外抑菌实验。结果紫冰霜对家兔完整皮肤和破损皮肤无急性毒性和刺激性；对豚鼠完整皮肤无致敏作用；对金黄色葡萄球菌、溶血性链球菌、大肠杆菌、铜绿假单胞菌、白色假丝酵母菌具有体外抑菌作用。结论紫冰霜对上述致病菌有一定的抑菌作用，并在治疗过程中具有较好的安全性。
목적：관찰자빙상대동물피부적독성작용급체외억균작용。방법채용건강가토진행피부급성독성실험화피부자격성실험；채용돈서진행피부치민성실험；채용지편법진행체외억균실험。결과자빙상대가토완정피부화파손피부무급성독성화자격성；대돈서완정피부무치민작용；대금황색포도구균、용혈성련구균、대장간균、동록가단포균、백색가사효모균구유체외억균작용。결론자빙상대상술치병균유일정적억균작용，병재치료과정중구유교호적안전성。
Objective To observe the toxicity and antibacterial activity in vitro of Zibing Cream on animal skin .Methods The acute toxicity and irritation experiments of skin were studied on healthy rabbits .The hypersensitivity experiment of skin was performed on guinea pigs .The test of antibacterial activity in vitro was performed with paper disk method .Results Zibing Cream had no a-cute toxicity and irritation on the intact skin and damaged skin of rabbit ,and had no hypersensitive effects on the intact skin of guinea pig .Zibing Cream can inhibit the growth of Staphylococcus aureus ,Streptococcus hemolyticus ,Escherichia coli ,Pseudo-monas aeruginosa and Blastomyces albicans in vitro .Conclusion Zibing Cream was safe in the treatments of sebum eczema ,local scleroderma ,exfoliative cheilitis ,senile dry skin ,chapped hand and foot ,the first or second-degree burn ,scald ,wound infec-tions ,bed sores and other skin diseases .