CAJ | 학술논문

目的：进一步明确钩吻素子是否具有抗焦虑作用。方法以大鼠高架十字迷宫实验为动物模型，评价钩吻素子单次皮下注射给药和连续皮下注射给药的抗焦虑活性及特点。结果钩吻素子能显著增加大鼠进入高架十字迷宫开臂次数和在开臂的停留时间百分率（P＜0．05，P＜0．01）；钩吻素子在实验剂量下对大鼠自主运动活性无影响（P＞0．05）。结论钩吻素子可能具有抗焦虑作用。
목적：진일보명학구문소자시부구유항초필작용。방법이대서고가십자미궁실험위동물모형，평개구문소자단차피하주사급약화련속피하주사급약적항초필활성급특점。결과구문소자능현저증가대서진입고가십자미궁개비차수화재개비적정류시간백분솔（P＜0．05，P＜0．01）；구문소자재실험제량하대대서자주운동활성무영향（P＞0．05）。결론구문소자가능구유항초필작용。
Objective To observe the anxiolytic effects of koumine .Methods Effects of acute subcutaneous administration and con-secutively subcutaneous administration of koumine on antianxiety activity were observed and evaluated by using the rat elevated plus maze model .Results Koumine exhibited significant increases in the percentage of open arm entries and the percent time spent in open arms(P< 0 .05 ,P< 0 .01) .Moreover ,no effect on the locomotor activity of rats was accompanied in experimental doses(P> 0 .05) .Conclusion Koumine may have anxiolytic effects .