CAJ | 학술논문

目的：探索β-catenin在胃腺癌原发灶及转移淋巴结的表达情况，判断其是否与浸润程度相关及能否为胃癌浸润转移提供依据。方法免疫组织化学法对156例胃腺癌组织、40例对应转移淋巴结、12例正常胃黏膜组织进行β-catenin检测，分析β-catenin在胃腺癌及对应转移淋巴结的表达情况，明确β-catenin的表达与胃腺癌临床病理特征之间的关系，判断原发灶与转移淋巴结β-catenin表达有无差异性。结果β-catenin在正常胃组织细胞膜的阳性表达率为100．0％（12/12），在胃腺癌组织细胞膜的表达率为29．5％（46/156），在转移淋巴结细胞膜的表达率为10．0％（4/40）。β-catenin阳性表达与患者的年龄（χ2＝2．160，P＝0．142）、性别（χ2＝1．229，P＝0．268）无关，与肿瘤浸润深度（χ2＝4．032，P＝0．045）、肿瘤分化程度（χ2＝6．093，P＝0．048）、肿瘤分期（χ2＝4．591，P＝0．032）、淋巴结转移（χ2＝4．485，P＝0．034）有关；β-catenin的异常表达或表达缺失在胃腺癌转移淋巴结的发生率高于原发灶组织（χ2＝6．362，P＝0．012）。结论β-catenin可帮助判断胃腺癌恶性程度、肿瘤侵袭转移能力等生物学行为。
목적：탐색β-catenin재위선암원발조급전이림파결적표체정황，판단기시부여침윤정도상관급능부위위암침윤전이제공의거。방법면역조직화학법대156례위선암조직、40례대응전이림파결、12례정상위점막조직진행β-catenin검측，분석β-catenin재위선암급대응전이림파결적표체정황，명학β-catenin적표체여위선암림상병리특정지간적관계，판단원발조여전이림파결β-catenin표체유무차이성。결과β-catenin재정상위조직세포막적양성표체솔위100．0％（12/12），재위선암조직세포막적표체솔위29．5％（46/156），재전이림파결세포막적표체솔위10．0％（4/40）。β-catenin양성표체여환자적년령（χ2＝2．160，P＝0．142）、성별（χ2＝1．229，P＝0．268）무관，여종류침윤심도（χ2＝4．032，P＝0．045）、종류분화정도（χ2＝6．093，P＝0．048）、종류분기（χ2＝4．591，P＝0．032）、림파결전이（χ2＝4．485，P＝0．034）유관；β-catenin적이상표체혹표체결실재위선암전이림파결적발생솔고우원발조조직（χ2＝6．362，P＝0．012）。결론β-catenin가방조판단위선암악성정도、종류침습전이능력등생물학행위。
Objective To explore the expressions ofβ-catenin in gastric adenocarcinoma primary tumors and metastatic lymph nodes,and to determine if it is associated with infiltration degree and whether it can provide the basis for gastric cancer metastasis.Methods The expressions ofβ-catenin were detected in 156 patients with gastric adenocarcinoma specimens,40 cases with the corresponding lymph nodes and 12 cases of normal gastric tissues by the method of immunohistochemistry.The expressions ofβ-catenin in gastric adenocarcinoma and corre-sponding lymph node metastases were analysed.The relationship between the expression of β-catenin and the clinical pathological features of gastric adenocarcinoma was ascertained,and difference between them was observed.Results The positive expression rate ofβ-catenin in normal gastric tissue membrane was 100.0%(12/12).The expression rate ofβ-catenin was 29.5%(46/156)in adenocarcinoma cell membrane,and it was 10.0%(4/40)in metastatic lymph nodes cell membrane.The positive expression ofβ-catenin was not associated with patient′s age(χ2 =2.160,P=0.142),gender (χ2 =1.229,P=0.268),but it was associated with tumor infiltration degree (χ2 =4.032,P=0.045 ),degree of tumor differentiation (χ2 =6.093,P=0.048),tumor stage (χ2 =4.591,P=0.032),and metastasis lymph nodes (χ2 =4.485,P=0.034).The incidence of abnor-mal or loss expression ofβ-catenin in gastric adenocarcinoma metastatic lymph nodes was higer than that in gastric adenocarcinoma (χ2 =6.362,P=0.012).Conclusion The expression of β-catenin will be a great help to judge the biological behaviors such as the malignant degree of tumor and the capacity of tumor invasion and metas-tasis.