国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2014年
9期
672-674
,共3页
王鸿彪%李绪渊%林文照
王鴻彪%李緒淵%林文照
왕홍표%리서연%림문조
肾肿瘤%分子靶向治疗%血管内皮生长因子A
腎腫瘤%分子靶嚮治療%血管內皮生長因子A
신종류%분자파향치료%혈관내피생장인자A
Kidney neoplasms%Molecular targeted therapy%Vascular endothelial growth factor A
抗血管生成治疗是转移性肾细胞癌的标准治疗。近年来,肿瘤新生血管通路的众多抑制剂纷纷进入临床研究,部分靶向药物取得良好的临床疗效。其他信号通路阻断剂如哺乳动物雷帕霉素靶蛋白与成纤维生长因子受体通路抑制剂也取得一定的成果。
抗血管生成治療是轉移性腎細胞癌的標準治療。近年來,腫瘤新生血管通路的衆多抑製劑紛紛進入臨床研究,部分靶嚮藥物取得良好的臨床療效。其他信號通路阻斷劑如哺乳動物雷帕黴素靶蛋白與成纖維生長因子受體通路抑製劑也取得一定的成果。
항혈관생성치료시전이성신세포암적표준치료。근년래,종류신생혈관통로적음다억제제분분진입림상연구,부분파향약물취득량호적림상료효。기타신호통로조단제여포유동물뢰파매소파단백여성섬유생장인자수체통로억제제야취득일정적성과。
Targeted therapy of anti-angiogensis strategy is the standard treatment for metastatic renal cell cancer.In recent years,a number of new generation of anti-angiogensis agents have been tested in clinical trials,some of which have achieved promising outcomes.Other pathway inhibitors such as inhibitors of mamma-lian target of rapamycin and fibroblast growth factor receptor pathway have made progresses in some extent.