CAJ | 학술논문

作为核酸损伤修复过程的重要成员，切除修复交叉互补基因1（ERCC1）的表达情况与胃癌的发生发展密切相关。研究发现，ERCC1基因的多态性会改变该基因自身的表达，并对铂类化疗药物的敏感性和疗效产生影响，通过对基因多态性的检测可以指导胃癌患者的个体化化疗。
작위핵산손상수복과정적중요성원，절제수복교차호보기인1（ERCC1）적표체정황여위암적발생발전밀절상관。연구발현，ERCC1기인적다태성회개변해기인자신적표체，병대박류화료약물적민감성화료효산생영향，통과대기인다태성적검측가이지도위암환자적개체화화료。
As a crucial part of the DNA damage repair process,the expression of excision repair cross-complementing group 1 (ERCC1 )is closely related to the genesis and development of gastric cancer.Studies find that ERCC1 gene polymorphism can alter the expression of the gene itself,which affects the sensitivity and efficacy of platinum-based chemotherapy.Therefore,the detection of ERCC1 polymorphism may guide the indi-vidualized chemotherapy of the patients with gastric cancer.