CAJ | 학술논문

可变剪接作为基因的一种修饰方式，是真核细胞表达调控过程的重要因素。它使同一蛋白质编码基因能够产生多种转录本，极大地扩展了遗传信息的应用。在人类肿瘤细胞中前体信使RN A的可变剪接扮演着重要角色，一些重要基因通过可变剪接产生不同于正常细胞中的剪接异构体。这些肿瘤特异性剪接异构体的存在导致了肿瘤的发生、发展。深入探索肿瘤相关基因的可变剪接对肿瘤的诊断、治疗具有重要意义。
가변전접작위기인적일충수식방식，시진핵세포표체조공과정적중요인소。타사동일단백질편마기인능구산생다충전록본，겁대지확전료유전신식적응용。재인류종류세포중전체신사RN A적가변전접분연착중요각색，일사중요기인통과가변전접산생불동우정상세포중적전접이구체。저사종류특이성전접이구체적존재도치료종류적발생、발전。심입탐색종류상관기인적가변전접대종류적진단、치료구유중요의의。
As a way of gene modification,alternative splicing is an important factor of eukaryotic gene expression and regulation.It makes various transcripts from one protein-coding gene,and greatly extends the genetic information.Alternative splicing of pre-messenger RNA plays an important role in tumor cells.By alter-native splicing,some important genes can generate splicing variants different from those in normal cells.The existence of tumor-specific splicing variants leads to the occurrence and progression of tumor.Therefore,explo-ration on the alternative splicing of tumor-associated genes may be of great significance in tumor diagnosis and treatment.