CAJ | 학술논문

高尿酸血症和痛风是多种心脑血管和代谢疾病的危险因素，是高血压、肾动脉硬化结石、尿酸性肾病、糖尿病的发病和恶化因素。抗痛风药为一组通过抑制尿酸合成和促进尿酸排泄或分解而降低血、尿尿酸水平，或抑制粒细胞浸润而控制关节炎症，对抗痛风发作的药物，其合理应用和药学监护十分重要。通过查阅近年来国内、外相关文献和诊疗指南，对痛风的药物治疗与药学监护进行综述。药师应确立痛风的治疗靶标、按痛风的分期选择用药、针对痛风合并症积极治疗，并从规避诱发尿酸水平升高的药品、急性发作期禁忌的药品、水化和碱化治疗等若干监护点进行干预，体现现代药师在药物治疗中的价值。
고뇨산혈증화통풍시다충심뇌혈관화대사질병적위험인소，시고혈압、신동맥경화결석、뇨산성신병、당뇨병적발병화악화인소。항통풍약위일조통과억제뇨산합성화촉진뇨산배설혹분해이강저혈、뇨뇨산수평，혹억제립세포침윤이공제관절염증，대항통풍발작적약물，기합리응용화약학감호십분중요。통과사열근년래국내、외상관문헌화진료지남，대통풍적약물치료여약학감호진행종술。약사응학립통풍적치료파표、안통풍적분기선택용약、침대통풍합병증적겁치료，병종규피유발뇨산수평승고적약품、급성발작기금기적약품、수화화감화치료등약간감호점진행간예，체현현대약사재약물치료중적개치。
Gout and hyperuricemia is a risk factor for various cardiovascular , cerebrovascular and metabolic dis-eases and can cause the onset and deterioration of hypertension , renal arteriosclerosis stones , uric acid nephropathy and diabetes . Gout Suppressant as a group of medicines can reduce the level of uric acid by inhibiting the synthe-sis of uric acid and promoting the excretion or decomposition of uric acid , or to control joint inflammation and gout attacks by inhibiting granulocyte invasion . The reasonable medication and pharmaceutical care are of great impor-tance . In this paper a review was made on the drug therapy and pharmaceutical care of gout based on data re-search of related literature at home and abroad in recent years,as well as the guidelines for diagnosis and treatment. Pharmacist should establish the target for gout treatment , select drugs according to the staging of gout and treat ac-tively the patient with gout complications . Intervention was given according to the monitoring points such as avoid-ing use of the drugs which may elevate uric acid level and the forbidden drugs during acute exacerbation , and hy-dration and alkalization treatments , thus the role of pharmacist in medical treatment is presented .