CAJ | 학술논문

目的：探讨抗菌药物专项监管措施对Ⅰ类切口手术患者围术期抗菌药物预防使用的影响。方法：南京市高淳人民医院（以下简称“我院”）从2012年4月起对临床应用抗菌药物实行专项监管措施，对实施前（2012年1-3月，A组）、后（2013年1-3月， B组）Ⅰ类切口手术患者围术期抗菌药物使用情况进行对比分析。结果：实行专项监管措施后，我院Ⅰ类切口手术患者术前使用抗菌药物比例明显下降（P＜0?05），且以单一用药为主；使用的抗菌药物种类和频次方面，则以第1、2代头孢菌素及青霉素等非限制使用级抗菌药物为主；用药合理性明显提高，住院各项费用下降明显，与实施前比较，差异有统计学意义（ P＜0?05）。结论：对临床应用抗菌药物实行专项监管措施能有效提高医院Ⅰ类切口手术患者围术期预防性应用抗菌药物的合理性水平。
목적：탐토항균약물전항감관조시대Ⅰ류절구수술환자위술기항균약물예방사용적영향。방법：남경시고순인민의원（이하간칭“아원”）종2012년4월기대림상응용항균약물실행전항감관조시，대실시전（2012년1-3월，A조）、후（2013년1-3월， B조）Ⅰ류절구수술환자위술기항균약물사용정황진행대비분석。결과：실행전항감관조시후，아원Ⅰ류절구수술환자술전사용항균약물비례명현하강（P＜0?05），차이단일용약위주；사용적항균약물충류화빈차방면，칙이제1、2대두포균소급청매소등비한제사용급항균약물위주；용약합이성명현제고，주원각항비용하강명현，여실시전비교，차이유통계학의의（ P＜0?05）。결론：대림상응용항균약물실행전항감관조시능유효제고의원Ⅰ류절구수술환자위술기예방성응용항균약물적합이성수평。
OBJECTIVE:To investigate the effect of the implementation of specific regulatory measures on perioperative use of antibiotics in patients undergoing type Ⅰ incision operation. METHODS: The special regulatory measures were carried out in Nanjing Municipal Gaochun People’ s Hospital(“our hospital”) since Apr. 2013. The perioperative use of antibiotics in patients undergoing type I incision operation before vs. after intervention [ Group A (from Jan. 2012 to Mar. 2012) vs. Group B (from Jan. 2013 to Mar. 2013)] were analyzed. RESULTS:After the implementation of specific regulatory measures, the ratio of patients using antibiotics was significantly decreased as compared with before intervention (P<0?05), and the antibiotics were mostly used singly. In terms of drug types and application frequency, non-restricted level of antibiotics such as first and second generation cephalosporin and penicillin took the lead. The rationality in antibiotic use improved significantly, with hospitalization costs decreased significantly, showing statistically significant differences as compared with before intervention ( P < 0?05 ) . CONCLUSIONS: The implementation of special regulatory measures on clinical use of antibiotics effectively improved the rational level of the perioperative use of prophylactic antibiotics.