CAJ | 학술논문

目的：了解南通大学附属东台医院（以下简称“我院”）质子泵抑制剂（ PPI）使用情况，为临床合理用药及科学管理提供参考依据。方法：从医院信息系统（HIS）中提取2011-2013年我院质子泵抑制剂的品种、销售量、销售金额、用药频度（DDDs）、限定日费用（ DDC）等数据，进行回顾性统计、分析。结果：2011-2012年我院PPI的总DDDs及总销售金额呈增长趋势，2012-2013呈负增长，DDDs及销售金额排序前3位的药品分别是奥美拉唑、兰索拉唑、泮托拉唑；2013年注射用PPI的DDDs及销售金额所占比重较高；各药的DDC呈平稳趋势。结论：我院PPI临床使用广泛，存在无适应证使用、盲目预防性应用、偏爱使用注射剂型等不合理现象，需进一步加强和完善PPI临床应用与管理的制度建设，把PPI临床应用逐步转入制度化、规范化、常规化的管理轨道，形成长效工作机制，促进医院PPI临床应用与管理水平的持续改进。
목적：료해남통대학부속동태의원（이하간칭“아원”）질자빙억제제（ PPI）사용정황，위림상합리용약급과학관리제공삼고의거。방법：종의원신식계통（HIS）중제취2011-2013년아원질자빙억제제적품충、소수량、소수금액、용약빈도（DDDs）、한정일비용（ DDC）등수거，진행회고성통계、분석。결과：2011-2012년아원PPI적총DDDs급총소수금액정증장추세，2012-2013정부증장，DDDs급소수금액배서전3위적약품분별시오미랍서、란색랍서、반탁랍서；2013년주사용PPI적DDDs급소수금액소점비중교고；각약적DDC정평은추세。결론：아원PPI림상사용엄범，존재무괄응증사용、맹목예방성응용、편애사용주사제형등불합리현상，수진일보가강화완선PPI림상응용여관리적제도건설，파PPI림상응용축보전입제도화、규범화、상규화적관리궤도，형성장효공작궤제，촉진의원PPI림상응용여관리수평적지속개진。
OBJECTIVE:To evaluate the application of proton pump inhibitors ( PPI) in Dongtai Hospital Affiliated to Nantong University(“our hospital”) so as to provide reference for clinical rational use and scientific management of PPI. METHODS:The application data of PPIs in our hospital from 211 to 2013 including varieties, consumption amount and consumption sum, DDDs and defined daily cost ( DDC ) retrieved from hospital information system ( HIS ) were analyzed statistically. RESULTS:The total DDDs and total consumption sum of PPI in our hospital showed upward trend from 2011 to 2012 yet negative growth from 2012 to 2013. Omeprazole, lansoprazole and pantoprazole were ranked among the top three on DDDs list;the PPI for injection in 2013 took a great proportion in both DDDs and consumption sum. The DDC was stable for each PPI. CONCLUSIONS:PPI had extensive clinical use in our hospital. Irrational phenomena such as use of PPI in the absence of indications, blindly preventive use, preference for the use of PPI for injection were noted, thus the construction of system regarding clinical use and management of PPI needs to be strengthened and improved to achieve institutionalized, standardized and normalized management on clinical use of PPI and form long-term working mechanism to facilitate the continuous improvement in clinical application and management of PPI.