CAJ | 학술논문

目的：探讨分析绝经前后女性甲状腺功能亢进对骨密度的影响。方法：60例甲状腺功能亢进症女性患者根据生理期不同分为甲亢A组(绝经前)与甲亢B组(绝经后)，同时随机选取同地区的60例健康女性走位对照组，分别是健康A组(绝经前)与健康B组(绝经后)。测定女性甲亢患者与健康女性的骨密度，并进行比较。结果：甲亢组患者的骨密度要显著低于健康女性(P＜0.05)；线性回归分析结果显示：甲亢组患者的骨密度与绝经年限，病程，血清FT3水平呈负相关(P＜0.05)，与血清TSH水平呈正相关(P＜0.05)；Logistic分析结果显示：绝经年限(β=1.852，OR=6.373)、病程(β=1.629，OR=5.099)、FT3(β=1.979，OR=7.236)可能是导致女性甲亢患者并发骨质疏松的独立危险因素(P＜0.05)，TSH(β=-2.492，OR=0.083)是女性甲亢患者并发骨质疏松的独立保护因素(P＜0.05)。结论：女性甲状腺功能亢进患者的骨密度要显著低于正常的健康女性，尤其是绝经后患者更明显，故对绝境后女性甲亢患者治疗过程中需要注意骨质疏松的发生。
목적：탐토분석절경전후녀성갑상선공능항진대골밀도적영향。방법：60례갑상선공능항진증녀성환자근거생리기불동분위갑항A조(절경전)여갑항B조(절경후)，동시수궤선취동지구적60례건강녀성주위대조조，분별시건강A조(절경전)여건강B조(절경후)。측정녀성갑항환자여건강녀성적골밀도，병진행비교。결과：갑항조환자적골밀도요현저저우건강녀성(P＜0.05)；선성회귀분석결과현시：갑항조환자적골밀도여절경년한，병정，혈청FT3수평정부상관(P＜0.05)，여혈청TSH수평정정상관(P＜0.05)；Logistic분석결과현시：절경년한(β=1.852，OR=6.373)、병정(β=1.629，OR=5.099)、FT3(β=1.979，OR=7.236)가능시도치녀성갑항환자병발골질소송적독립위험인소(P＜0.05)，TSH(β=-2.492，OR=0.083)시녀성갑항환자병발골질소송적독립보호인소(P＜0.05)。결론：녀성갑상선공능항진환자적골밀도요현저저우정상적건강녀성，우기시절경후환자경명현，고대절경후녀성갑항환자치료과정중수요주의골질소송적발생。
Objective: To study the correlation factors of bone mineral density in patients with hyperthyroidism before and after menopause.Methods:60 female patients with hyperthyroidism were divided into the hyperthyroidism A group (pre-menopausal) and hyperthyroidism B group (post-menopausal).At the same time,60 healthy females of the same district were divided into the healthy A group (pre-menopausal) and healthy B group (post-menopausal).The bone mineral density was tested on the patients with hyperthyroidism and the healthy females.Results:The bone mineral density of the patients with hyperthyroidism was obviously lower than the healthy females (P<0.05).Linear regression analysis in patients with hyperthyroidism showed that bone mineral density had negatively correlation with menopause,duration,serum FT3 levels (P<0.05),and had positively correlation with serum TSH (P<0.05);Multivariate Logistic analysis showed that menopausal years(β=1.852,OR=6.373),the course of the disease(β=1.629,OR=5.099),FT3(β=1.979,OR=7.236) may be the independent risk factor for hyperthyroidism female patients with osteoporosis(P<0.05),and TSH(β=-2.492,OR=0.083) may be the independent protective factor for hyperthyroidism female patients with osteoporosis(P<0.05).Conclusion:The bone mineral density of the patients with hyperthyroidism was obviously lower than the healthy females,especially after menopause were more evident.Therefore,patients with hyperthyroidism after desperate need to prevent the occurrence of osteoporosis.