CAJ | 학술논문

目的：观察瑞舒伐他汀干预后不同严重程度的冠心病患者血清 Cys-c和 Hcy水平的变化。方法选择来我院就诊经冠状动脉造影确诊为冠心病患者40例（冠脉单支病变11例、冠脉双支病变16例和冠脉多支病变13例），分为两组（n＝40）：瑞舒伐他汀治疗前组和瑞舒伐他汀治疗后组（瑞舒伐他汀10 mg/d），同期体检健康人20例作为正常对照组；初次检查、治疗6个月后均空腹采血及冠状动脉造影。采用 ELISA法检测血清中Cys-c和 Hcy的水平；采用冠状动脉造影测定斑块的个数、厚度、性质。结果（1）治疗前与正常对照组相比较，患者血清Cys-c和 Hcy水平均显著升高有统计学意义（P＜0．01）；均为冠脉多支病变高于冠脉双支病变及冠脉单支病变，组间比较有统计学意义（P＜0．01）。（2）治疗后与正常对照组相比较，瑞舒伐他汀干预组患者血清Cys-c和 Hcy水平略升高且冠脉多支病变、冠脉双支病变、冠脉单支病变组均明显低于治疗前（P＜0．01），但三组间无统计学意义（P＞0．05）。（3）瑞舒伐他汀干预组治疗后患者血清Cys-c和 Hcy水平明显低于治疗前有统计学意义（P＜0．01），斑块个数无差异（P＞0．05），斑块厚度变薄、斑块由软斑块变为硬斑块的百分率大（P＜0．01）。结论血清Cys-c和 Hcy水平随病变严重程度而升高，瑞舒伐他汀能通过降低血清Cys-c和 Hcy水平，使得斑块变薄，并能促进斑块硬化，从而改善冠心病患者冠状动脉病变的程度。
목적：관찰서서벌타정간예후불동엄중정도적관심병환자혈청 Cys-c화 Hcy수평적변화。방법선택래아원취진경관상동맥조영학진위관심병환자40례（관맥단지병변11례、관맥쌍지병변16례화관맥다지병변13례），분위량조（n＝40）：서서벌타정치료전조화서서벌타정치료후조（서서벌타정10 mg/d），동기체검건강인20례작위정상대조조；초차검사、치료6개월후균공복채혈급관상동맥조영。채용 ELISA법검측혈청중Cys-c화 Hcy적수평；채용관상동맥조영측정반괴적개수、후도、성질。결과（1）치료전여정상대조조상비교，환자혈청Cys-c화 Hcy수평균현저승고유통계학의의（P＜0．01）；균위관맥다지병변고우관맥쌍지병변급관맥단지병변，조간비교유통계학의의（P＜0．01）。（2）치료후여정상대조조상비교，서서벌타정간예조환자혈청Cys-c화 Hcy수평략승고차관맥다지병변、관맥쌍지병변、관맥단지병변조균명현저우치료전（P＜0．01），단삼조간무통계학의의（P＞0．05）。（3）서서벌타정간예조치료후환자혈청Cys-c화 Hcy수평명현저우치료전유통계학의의（P＜0．01），반괴개수무차이（P＞0．05），반괴후도변박、반괴유연반괴변위경반괴적백분솔대（P＜0．01）。결론혈청Cys-c화 Hcy수평수병변엄중정도이승고，서서벌타정능통과강저혈청Cys-c화 Hcy수평，사득반괴변박，병능촉진반괴경화，종이개선관심병환자관상동맥병변적정도。
Objective To observe the change of Cys-c and Hcy level in the serum of the coronary heart disease pa-tients with different severity after the intervention of rosuvastatin.Methods Options to our hospital diagnosed by coro-nary angiography 40 patients with coronary heart disease (single vessel coronary artery disease 1 1 cases,dual vessel cor-onary artery disease 16 cases,multi-vessel coronary artery disease 13 cases),divided into two groups(n=40):Before treatment with rosuvastatin group and rosuvastatin treatment group(rosuvastatin 10 mg/d),physical health of people 20 cases over the same period as the normal control group;Initial inspection,after 6 months of treatment both fasting blood and coronary angiography.Detected by ELISA in serum Cys-c and Hcy level;Measured by coronary angiography plaque number,thickness,nature.Results (1)Before treatment compared with the control group,Cys-c and Hcy level in the serum of the patients were significantly higher statistically significant(P<0.01);Coronary multi-vessel disease are higher than double coronary artery disease and higher than single vessel disease and have statistically significant(P<0.01);(2)After treatment compared with the control group,Cys-c and Hcy level in the serum of rosuvastatin inter-vention groups were slightly elevated and among multi-vessel disease,double coronary artery disease and single vessel coronary artery disease was not statistically significant(P>0.05).(3)Rosuvastatin intervention groups the levels of Cys-c and Hcy in the serum were significantly lower than before treatment was statistically significant(P<0.01),no difference in the number of plaques(P>0.05),plaque thickness thining spots large blocks into soft plaque and hard plaque percentage(P<0.01).Conclusion Serum Cys-c and Hcy levels increased with disease severity,rosuvastatin by reducing serum Cys-c and Hcy levels,making the plaque thining and promote plaque sclerosis,thereby improving coro-nary heart disease severity of coronary artery disease.