CAJ | 학술논문

目的：研究莫匹罗星、利奈唑胺、万古霉素和替加环素对甲氧西林耐药的金黄色葡萄球菌（MRSA）的体外活性。方法采用 E-试验法对2010年1月～2011年6月我院分离的88株 MRSA进行莫匹罗星、利奈唑胺、万古霉素和替加环素的 MIC检测，并比较 MIC50和 MIC90的大小。结果莫匹罗星、利奈唑胺、万古霉素和替加环素对MRSA的体外活性均较好，全部敏感且表现为极低的 MIC值。其中莫匹罗星和替加环素的 MIC90均未超过0．25μg/mL。结论莫匹罗星、利奈唑胺、万古霉素和替加环素对 MRSA活性较好，可作为 MRSA感染治疗的有效选择，莫匹罗星是治疗 MRSA相关的皮肤和浅表外伤感染的有效的局部外用抗菌药物。
목적：연구막필라성、리내서알、만고매소화체가배소대갑양서림내약적금황색포도구균（MRSA）적체외활성。방법채용 E-시험법대2010년1월～2011년6월아원분리적88주 MRSA진행막필라성、리내서알、만고매소화체가배소적 MIC검측，병비교 MIC50화 MIC90적대소。결과막필라성、리내서알、만고매소화체가배소대MRSA적체외활성균교호，전부민감차표현위겁저적 MIC치。기중막필라성화체가배소적 MIC90균미초과0．25μg/mL。결론막필라성、리내서알、만고매소화체가배소대 MRSA활성교호，가작위 MRSA감염치료적유효선택，막필라성시치료 MRSA상관적피부화천표외상감염적유효적국부외용항균약물。
Objective To study antimicrobial efficiency of Mupirocin,Linezolid,Vancomycin and Tigecycline against MRSA in vitro.Methods Antimicrobial efficiency of antibiotics were performed with E-test among a total of 88 unique strains of MRSA isolated from Jan 2010 to Jun 2010 in our hospital.MIC50 and MIC90 were analyzed.Results There was perfect antimicrobial effiency in these Antibiotics against MRSA with low MIC,MIC value of Mupirocin and Tige-cycline were less than 0.25μg/mL.Conclusion Mupirocin,Linezolid,Vancomycin and Tigecycline could be good choice for clinical therapy of serious infection caused by MRSA,especially Mupirocin used for topical infection.