CAJ | 학술논문

目的：探讨克罗恩病患者人体成分的特点。方法前瞻性选取2012年12月至2013年12月间中山大学附属第六医院收治的57例克罗恩病患者（克罗恩病组），并选择同期进行健康体检的51名健康人（健康对照组），利用生物电阻抗分析法对其进行人体成分分析，测量蛋白质含量、脂肪含量、矿物质含量、瘦组织群、腰围和臀围等指标。并比较不同发病部位和不同疾病活动度克罗恩病患者人体成分的差异。结果克罗恩病组患者的细胞内、外液量、体质量、蛋白总量、脂肪总量、瘦组织总量、肌肉重量、身体脂肪比率、腰臀比、体质量、肥胖度、手臂肌肉围度、手臂围度、体内细胞质量、体质量指数和基础代谢率均明显低于健康组（均P＜0．05）。克罗恩病组蛋白质和脂肪缺乏人数比例分别为66．7％（38/57）和47．4％（27/57）。克罗恩病回结肠型患者机体水、蛋白质、脂肪和瘦组织总量明显低于小肠型和结肠型（均P＜0．05）；高疾病活动度患者机体水、蛋白质、脂肪以及瘦组织总量明显低于中、低活动度患者（P＜0．05），而基础代谢率明显高于中、低活动度患者（P＜0．05）。结论克罗恩病患者的人体成分各项指标较健康人群明显降低；发病部位和疾病活动度对克罗恩病患者机体水分、蛋白质、脂肪和瘦组织总量具有显著影响。
목적：탐토극라은병환자인체성분적특점。방법전첨성선취2012년12월지2013년12월간중산대학부속제륙의원수치적57례극라은병환자（극라은병조），병선택동기진행건강체검적51명건강인（건강대조조），이용생물전조항분석법대기진행인체성분분석，측량단백질함량、지방함량、광물질함량、수조직군、요위화둔위등지표。병비교불동발병부위화불동질병활동도극라은병환자인체성분적차이。결과극라은병조환자적세포내、외액량、체질량、단백총량、지방총량、수조직총량、기육중량、신체지방비솔、요둔비、체질량、비반도、수비기육위도、수비위도、체내세포질량、체질량지수화기출대사솔균명현저우건강조（균P＜0．05）。극라은병조단백질화지방결핍인수비례분별위66．7％（38/57）화47．4％（27/57）。극라은병회결장형환자궤체수、단백질、지방화수조직총량명현저우소장형화결장형（균P＜0．05）；고질병활동도환자궤체수、단백질、지방이급수조직총량명현저우중、저활동도환자（P＜0．05），이기출대사솔명현고우중、저활동도환자（P＜0．05）。결론극라은병환자적인체성분각항지표교건강인군명현강저；발병부위화질병활동도대극라은병환자궤체수분、단백질、지방화수조직총량구유현저영향。
Objective To investigate the differences in body composition between Crohn′s disease (CD) patients and healthy subjects as well as the characteristics of human body composition in various types of CD. Methods A total of 57 CD patients were prospectively selected from the Sixth Affiliated Hospital of Sun Yat-sen University as the study group, while 51 healthy subjects as the control group. Protein content, mineral content, fat content, lean body mass, waist circumference, and hip circumference in the two groups were measured by body composition analyzer. Characteristics of CD at different location and different disease activity index were investigated as well. Results Intracellular fluid, extracellular fluid, weight, protein content, fat content, lean body mass, muscle weight, body fat ratio, waist hip ratio, body weight ratio, arm muscle circumference, arm circumference, quality of cells, BMI and basal metabolic rate in CD patients were significantly lower than those in control group (all P<0.05). Proportion of protein-deficiency patients and fat-deficiency patients were 66.7% and 47.4% respectively. Protein content, fat content, and lean body mass in ileocolic CD patients were lower than those with small bowel and colonic CD (all P<0.05). Protein content, fat content, lean body mass in patients with high disease activity index were lower than those in patients with low and medium index, but higher basal metablic rate was found in the former group (all P<0.05). Conclusions The human body composition in patients with CD are different from healthy people. Disease location and disease activity index have an impact on protein content, fat content, and lean body mass.