CAJ | 학술논문

目的：比较盐酸去甲乌药碱（HG）负荷心肌灌注显像（MPI）和负荷心电图（ECG）对冠心病的诊断价值。方法70例患者同时完成HG负荷核素MPI及冠脉造影（CAG）检查，在心肌灌注负荷试验过程中观察ECG变化，并与同期负荷MPI和冠脉造影结果作对比。结果以CAG结果为金标准，HG负荷MPI诊断冠心病的敏感性、特异性、阳性预测值、阴性预测值、准确性分别为55.8%、92.6%、92.3%、56.8%、70%，HG负荷ECG诊断冠心病的敏感性、特异性、阳性预测值、阴性预测值、准确性分别为74.4%、29.6%、62.7%、42.1%、57.1%。MPI的特异性和阳性预测值明显高于ECG（P＜0.01），敏感性、阴性预测值、准确性两者统计学差异不大（P＞0.05）。结论 HG可作为负荷MPI和负荷ECG药物来诊断冠心病，且HG负荷MPI的特异性要优于HG负荷ECG。
목적：비교염산거갑오약감（HG）부하심기관주현상（MPI）화부하심전도（ECG）대관심병적진단개치。방법70례환자동시완성HG부하핵소MPI급관맥조영（CAG）검사，재심기관주부하시험과정중관찰ECG변화，병여동기부하MPI화관맥조영결과작대비。결과이CAG결과위금표준，HG부하MPI진단관심병적민감성、특이성、양성예측치、음성예측치、준학성분별위55.8%、92.6%、92.3%、56.8%、70%，HG부하ECG진단관심병적민감성、특이성、양성예측치、음성예측치、준학성분별위74.4%、29.6%、62.7%、42.1%、57.1%。MPI적특이성화양성예측치명현고우ECG（P＜0.01），민감성、음성예측치、준학성량자통계학차이불대（P＞0.05）。결론 HG가작위부하MPI화부하ECG약물래진단관심병，차HG부하MPI적특이성요우우HG부하ECG。
Objective To compare the diagnosis values of stress myocardial perfusion imaging (MPI) and stress electrocardiogram (ECG) with Higenamine Hydrochloride (HG) in coronary heart disease (CHD). Methods In the process of stress test with HG for myocardial perfusion, observe the ECG changes of 70 patients who simultaneously underwent the examinations of both stress MPI with HG and coronary angiography (CAG), and then compare the results with those of stress MPI and CAG. Results With the results of CAG as the gold standard, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of stress MPI in diagnosing CHD were 55.8%, 92.6%, 92.3%, 56.8%and 70%, respectively, while those of stress ECG were 74.4%, 29.6%, 62.7%, 42.1% and 57.1%, respectively. Thus, the speciifcity and positive predictive value of stress MPI in diagnosing CHD were obviously higher than those of stress ECG (P<0.01) while there was no signiifcant difference in the sensitivity, negative predictive value and accuracy between stress MPI and stress ECG in diagnosing CHD (P>0.05). Conclusion HG can be used as a drug for stress MPI and stress ECG to diagnose CHD while the speciifcity of stress MPI is higher than that of stress ECG.