CAJ | 학술논문

目的：探讨尿毒症瘙痒的有效治疗方法。方法选取我院血液透析中心2012年维持性血液透析治疗的尿毒症患者34例，随机分为2组，18例为观察组，每周在2次血液透析的基础上，加1次连续床旁静脉-静脉血液透析滤过（CVVHDF），16例为对照组，每周在2次血液透析基础上加1次血液灌流，检测治疗前及3个月后的皮肤瘙痒情况，血肌酐、尿素氮及甲状旁腺激素水平。结果2组患者的睡眠质量、食欲、高血压、皮肤瘙痒等症状均有改善，但观察组改善更明显（P<0.05），2组患者治疗后血肌酐、甲状旁腺激素、β2-微球蛋白水平显著降低，差异有统计学意义（P<0.05）。尿素氮水平治疗前后2组比较差异无统计学意义（P>0.05）。结论应用连续性肾脏替代疗法治疗尿毒症皮肤瘙痒，疗效显著，明显优于血液灌流组。
목적：탐토뇨독증소양적유효치료방법。방법선취아원혈액투석중심2012년유지성혈액투석치료적뇨독증환자34례，수궤분위2조，18례위관찰조，매주재2차혈액투석적기출상，가1차련속상방정맥-정맥혈액투석려과（CVVHDF），16례위대조조，매주재2차혈액투석기출상가1차혈액관류，검측치료전급3개월후적피부소양정황，혈기항、뇨소담급갑상방선격소수평。결과2조환자적수면질량、식욕、고혈압、피부소양등증상균유개선，단관찰조개선경명현（P<0.05），2조환자치료후혈기항、갑상방선격소、β2-미구단백수평현저강저，차이유통계학의의（P<0.05）。뇨소담수평치료전후2조비교차이무통계학의의（P>0.05）。결론응용련속성신장체대요법치료뇨독증피부소양，료효현저，명현우우혈액관류조。
Objective To investigate the treatment effective of cutaneous pruritus caused by uraemia. Methods Thirty-four uraemia patients underwent maintenance hemodialysis during 2012 were adopted and divided into 2 groups randomly. The observed group (18 cases) were given CVVHDF therapy once combining with the hemodialysis twice a week. The control group (16 cases) were given perfusion once combining with the hemodialysis twice a week. The cutaneous pruritus, serum creatinine, urea nitrogen, and parathyroid hormone were measured before treatment and 3 months after therapy. Results The sleep quality, appetite, hypertension, and cutaneous pruritus were ameliorated in all groups. The observed group exhibited better amelioration in symptoms. Both groups showed lower serum creatinine , urea nitrogen, and parathyroid hormone level. However, there was no difference in β2-microglobulin before and after therapy. Conclusion Continuous renal replacement therapy is better than perfusion therapy in the treatment of cutaneous pruritus caused by uraemia.