CAJ | 학술논문

目的观察2型糖尿病患者使用沙格列汀联合二甲双胍治疗后血糖的控制情况及血脂、体重指数的变化。方法选择40例2型糖尿病患者，随机分为2组。联合组20例，使用沙格列汀5 mg/d＋二甲双胍2000 mg/d；对照组20例，使用二甲双胍2000 mg/d，治疗3个月。检测治疗前后空腹血糖（ FPG）、餐后2 h血糖（PPG）、HbA1c、血脂、体重指数等，观察低血糖事件及其他不良反应。结果治疗后，联合组和对照组的空腹血糖、餐后血糖和糖化血红蛋白均显著下降，两组餐后血糖比较差异有统计学意义（P＜0.05），低血糖发生率比较差异无统计学意义（P＞0.05），且均未见严重不良反应。结论沙格列汀联合二甲双胍可改善2型糖尿病患者的血糖控制，无严重低血糖事件及其他不良反应。
목적관찰2형당뇨병환자사용사격렬정연합이갑쌍고치료후혈당적공제정황급혈지、체중지수적변화。방법선택40례2형당뇨병환자，수궤분위2조。연합조20례，사용사격렬정5 mg/d＋이갑쌍고2000 mg/d；대조조20례，사용이갑쌍고2000 mg/d，치료3개월。검측치료전후공복혈당（ FPG）、찬후2 h혈당（PPG）、HbA1c、혈지、체중지수등，관찰저혈당사건급기타불량반응。결과치료후，연합조화대조조적공복혈당、찬후혈당화당화혈홍단백균현저하강，량조찬후혈당비교차이유통계학의의（P＜0.05），저혈당발생솔비교차이무통계학의의（P＞0.05），차균미견엄중불량반응。결론사격렬정연합이갑쌍고가개선2형당뇨병환자적혈당공제，무엄중저혈당사건급기타불량반응。
Objective To observe the effect of saxagliptin combined with metformin on blood glucose,low-density lipoproteinin and BMI of patients with type 2 diabetes.Methods Forty patients were randomly divided into two groups:combined treatment group ( group A) and control group ( group B) .Patients in group A were given met-formin,2 000 mg/d,patients in group B were given the same dose of metformin with group A and saxagliptin 5 mg/d. After treatment of 3 months,the change of fasting glucose ( FPG) ,2 h postprandial glucose ( PPG) ,glycated hemoglo-bin (HbA1c),cholesterol,body mass index and adverse reactions of the patients in the two groups were compared.Re-sults The FPG,PPG,HbA1c in group A decreased more significantly than that in group B(P<0.05).There was no serious adverse reaction in the two groups( P>0.05 ) .Conclusion The blood glucose can be controlled in patients u-sing saxagliptin and metformin with no serious hypoglycemia and other adverse reactions.