实用药物与临床
實用藥物與臨床
실용약물여림상
PRACTICAL PHARMACY AND CLINICAL REMEDIES
2014年
10期
1353-1357
,共5页
还原型谷胱甘肽%生长抑素%重症急性胰腺炎
還原型穀胱甘肽%生長抑素%重癥急性胰腺炎
환원형곡광감태%생장억소%중증급성이선염
Reduced glutathione%Somatostatin%Severe acute pancreatitis
目的观察还原型谷胱甘肽联合生长抑素治疗重症急性胰腺炎的效果，为临床重症急性胰腺炎的治疗提供参考。方法选择2010年8月至2013年8月来我科住院治疗的重症急性胰腺炎患者52例，采用随机数字法平均分为观察组和对照组。在常规治疗基础上，观察组采用还原型谷胱甘肽联合生长抑素进行治疗，对照组使用生长抑素进行治疗。比较两组的症状及体征恢复正常时间、胃肠道功能恢复时间、血清淀粉酶及血清脂肪酶恢复正常时间、肝功能、炎性细胞因子、氧化指标、并发症发生情况、死亡例数。结果观察组腹痛、腹胀、胃肠道功能、血清淀粉酶、脂肪酶恢复正常时间明显短于对照组，差异有统计学意义（ P＜0.05）；体温恢复正常时间略短于对照组，但差异无统计学意义（ P＞0.05）。治疗后，观察组ALT、AST、TB、γ-GT、IL-6、IL-8、CRP、TNF-α、MDA、SOD均明显低于对照组，差异有统计学意义（ P＜0.05）；IL-10、GSH-Px明显高于对照组，差异有统计学意义（ P＜0.05）。观察组呼吸窘迫综合征、肝功能衰竭、胰腺假性囊肿、脓肿发生例数及死亡例数均略低于对照组，差异无统计学意义（ P＞0.05）。结论还原型谷胱甘肽联合生长抑素治疗重症急性胰腺炎具有症状缓解时间短、胃肠道功能恢复快、保护肝功能、抗炎及抗氧化作用强、并发症发生较少等优点，是一种有效的治疗方式，值得临床借鉴使用。
目的觀察還原型穀胱甘肽聯閤生長抑素治療重癥急性胰腺炎的效果，為臨床重癥急性胰腺炎的治療提供參攷。方法選擇2010年8月至2013年8月來我科住院治療的重癥急性胰腺炎患者52例，採用隨機數字法平均分為觀察組和對照組。在常規治療基礎上，觀察組採用還原型穀胱甘肽聯閤生長抑素進行治療，對照組使用生長抑素進行治療。比較兩組的癥狀及體徵恢複正常時間、胃腸道功能恢複時間、血清澱粉酶及血清脂肪酶恢複正常時間、肝功能、炎性細胞因子、氧化指標、併髮癥髮生情況、死亡例數。結果觀察組腹痛、腹脹、胃腸道功能、血清澱粉酶、脂肪酶恢複正常時間明顯短于對照組，差異有統計學意義（ P＜0.05）；體溫恢複正常時間略短于對照組，但差異無統計學意義（ P＞0.05）。治療後，觀察組ALT、AST、TB、γ-GT、IL-6、IL-8、CRP、TNF-α、MDA、SOD均明顯低于對照組，差異有統計學意義（ P＜0.05）；IL-10、GSH-Px明顯高于對照組，差異有統計學意義（ P＜0.05）。觀察組呼吸窘迫綜閤徵、肝功能衰竭、胰腺假性囊腫、膿腫髮生例數及死亡例數均略低于對照組，差異無統計學意義（ P＞0.05）。結論還原型穀胱甘肽聯閤生長抑素治療重癥急性胰腺炎具有癥狀緩解時間短、胃腸道功能恢複快、保護肝功能、抗炎及抗氧化作用彊、併髮癥髮生較少等優點，是一種有效的治療方式，值得臨床藉鑒使用。
목적관찰환원형곡광감태연합생장억소치료중증급성이선염적효과，위림상중증급성이선염적치료제공삼고。방법선택2010년8월지2013년8월래아과주원치료적중증급성이선염환자52례，채용수궤수자법평균분위관찰조화대조조。재상규치료기출상，관찰조채용환원형곡광감태연합생장억소진행치료，대조조사용생장억소진행치료。비교량조적증상급체정회복정상시간、위장도공능회복시간、혈청정분매급혈청지방매회복정상시간、간공능、염성세포인자、양화지표、병발증발생정황、사망례수。결과관찰조복통、복창、위장도공능、혈청정분매、지방매회복정상시간명현단우대조조，차이유통계학의의（ P＜0.05）；체온회복정상시간략단우대조조，단차이무통계학의의（ P＞0.05）。치료후，관찰조ALT、AST、TB、γ-GT、IL-6、IL-8、CRP、TNF-α、MDA、SOD균명현저우대조조，차이유통계학의의（ P＜0.05）；IL-10、GSH-Px명현고우대조조，차이유통계학의의（ P＜0.05）。관찰조호흡군박종합정、간공능쇠갈、이선가성낭종、농종발생례수급사망례수균략저우대조조，차이무통계학의의（ P＞0.05）。결론환원형곡광감태연합생장억소치료중증급성이선염구유증상완해시간단、위장도공능회복쾌、보호간공능、항염급항양화작용강、병발증발생교소등우점，시일충유효적치료방식，치득림상차감사용。
Objective To observe the clinical efficacy of reduced glutathione combined with somatostatin in the treatment of severe acute pancreatitis,and provide reference for the treatment of severe acute pancreatitis (SAP). Methods 52 patients of SAP in our hospital were chosen from August 2010 to August 2013 .They were divided into observation group and control group by random number method.Both groups received routine therapy, observation group received reduced glutathione combined with somatostatin treatment, control group received somatostatin treat-ment.The symptoms and signs recovery time,gastrointestinal function recovery time,time of serum amylase and serum lipase returning to normal level, liver function, inflammatory cytokines, oxidative index, the occurrence of complica-tions,the number of deaths of the two groups were observed and compared.Results The abdominal pain,bloating, gastrointestinal function,serum amylase,lipase recovery time in observation group were significantly shorter than those of control group,there were significant differences between the two groups ( P <0.05 );the temperature returning to normal time was shorter than that of control group,but there was no significant difference between the two groups ( P>0.05).After treatment,the ALT,AST,TB,γ-GT,IL-6,IL-8,CRP,TNF-α,MDA,SOD in observation group were sig-nificantly lower than those of control group,there were significant differences between the two groups (P<0.05);IL-10 and GSH-Px in observation group were significantly higher than those of control group,there were significant differ-ences between the two groups ( P <0.05 ) .The number of respiratory distress syndrome, hepatic failure, pancreatic pseudocysts,abscesses and death was slightly lower than that of control group,there was no significant difference be-tween the two groups ( P>0.05 ) .Conclusion Reduced glutathione combined with somatostatin is effective for the treatment of SAP,with short symptom recovery time,protective effect on liver function,good anti-inflammatory and an-tioxidant effect,fewer complications,etc.It is worthy of clinical use.
