实用药物与临床
實用藥物與臨床
실용약물여림상
PRACTICAL PHARMACY AND CLINICAL REMEDIES
2014年
10期
1269-1271
,共3页
慢性病毒性肝炎%甲状腺功能异常%干扰素%危险因素
慢性病毒性肝炎%甲狀腺功能異常%榦擾素%危險因素
만성병독성간염%갑상선공능이상%간우소%위험인소
Chronic viral hepatitis%Thyroid dysfunction%Interferon%Influencing factors
目的：研究干扰素( IFN)治疗慢性病毒性肝炎引起甲状腺功能异常的危险因素。方法选择385例慢性病毒性肝炎患者,给予IFN治疗后,分析影响甲状腺功能异常的危险因素。结果385例接受IFN治疗的慢性病毒性肝炎患者中,32例(8．3%)甲状腺功能出现异常。甲状腺功能正常组的基线及治疗12、36、48周后的甲状腺抗体阳性率显著低于异常组(P<0．05)。甲状腺过氧化物酶抗体(TPOAb)及女性为IFN治疗后甲状腺功能异常的独立危险因素。结论 TPOAb水平及女性患者为INF治疗慢性病毒性肝炎引起甲状腺功能异常的独立危险因素。
目的：研究榦擾素( IFN)治療慢性病毒性肝炎引起甲狀腺功能異常的危險因素。方法選擇385例慢性病毒性肝炎患者,給予IFN治療後,分析影響甲狀腺功能異常的危險因素。結果385例接受IFN治療的慢性病毒性肝炎患者中,32例(8．3%)甲狀腺功能齣現異常。甲狀腺功能正常組的基線及治療12、36、48週後的甲狀腺抗體暘性率顯著低于異常組(P<0．05)。甲狀腺過氧化物酶抗體(TPOAb)及女性為IFN治療後甲狀腺功能異常的獨立危險因素。結論 TPOAb水平及女性患者為INF治療慢性病毒性肝炎引起甲狀腺功能異常的獨立危險因素。
목적：연구간우소( IFN)치료만성병독성간염인기갑상선공능이상적위험인소。방법선택385례만성병독성간염환자,급여IFN치료후,분석영향갑상선공능이상적위험인소。결과385례접수IFN치료적만성병독성간염환자중,32례(8．3%)갑상선공능출현이상。갑상선공능정상조적기선급치료12、36、48주후적갑상선항체양성솔현저저우이상조(P<0．05)。갑상선과양화물매항체(TPOAb)급녀성위IFN치료후갑상선공능이상적독립위험인소。결론 TPOAb수평급녀성환자위INF치료만성병독성간염인기갑상선공능이상적독립위험인소。
Objective To study the risk factors of abnormal thyroid function in chronic viral hepatitis treated with interferon. Methods 385 patients with chronic viral hepatitis were selected as the research object,and risk factors of abnormal thyroid function were analyzed after IFN treatment. Results Thyroid dysfunction was found in 32 patients among 385 (8. 3%) chronic viral hepatitis patients after IFN treatment. Thyroid antibody positive rates of normal thy-roid function group at baseline and after treating for 12,36,48 weeks were lower than those of abnormal thyroid func-tion group ( P<0. 05 ) . Serum TPOAb levels and women were independent risk factors for thyroid dysfunction after IFN treatment. Conclusion Serum TPOAb levels and women are independent risk factor for thyroid dysfunction after IFN treatment.
