CAJ | 학술논문

目的：观察化浊通脉散对ASO家兔IL-1表达的影响,并对其发生机制进行初步探讨。方法50只新西兰家兔以高脂饮食和股动脉球囊扩张后建立 ASO 动物模型,随机分为5组,即正常组( A )、模型组( B)、化浊通脉散组( C)、西洛他唑组( D)、通塞脉片组( E)。各组分别测定药物干预前后总胆固醇( TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,实验结束后应用RT-PCR方法检测IL-1的表达。结果与模型组比较,化浊通脉散组ASO家兔IL-1表达显著降低(P<0．01),TC、TG、LDL-C等亦降低(P<0．01),但HDL-C未出现明显升高。结论化浊通脉散具有降脂作用,能显著降低IL-1的表达,可保护动脉血管内膜,延缓动脉粥样硬化形成。
목적：관찰화탁통맥산대ASO가토IL-1표체적영향,병대기발생궤제진행초보탐토。방법50지신서란가토이고지음식화고동맥구낭확장후건립 ASO 동물모형,수궤분위5조,즉정상조( A )、모형조( B)、화탁통맥산조( C)、서락타서조( D)、통새맥편조( E)。각조분별측정약물간예전후총담고순( TC)、삼선감유(TG)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)수평,실험결속후응용RT-PCR방법검측IL-1적표체。결과여모형조비교,화탁통맥산조ASO가토IL-1표체현저강저(P<0．01),TC、TG、LDL-C등역강저(P<0．01),단HDL-C미출현명현승고。결론화탁통맥산구유강지작용,능현저강저IL-1적표체,가보호동맥혈관내막,연완동맥죽양경화형성。
Objective To study the effect of Huazhuo Tongmai Powder on expression of IL-1 of ASO rabbit and explore the mechanism. Methods The ASO was reproduced in 50 New Zealand rabbits with high fat diet and fem-oral artery balloon injury. The rabbits were randomly divided into 5 groups:Normal group (A),High fat diet group ( B) ,Huazhuo Tongmai Powder group ( C) ,Cilostazol group ( D) and Tongmaiyin Pill group ( E) . The level of TC, TG,HDL-C and LDL-C were determined before and after drug intervention. The expression of IL-1 was measured with RT-PCR. Results Huazhuo Tongmai Powder could significantly decrease the expression of IL-1 of ASO rabbit ( P<0. 01),and decrease the level of TC,TG and LDL-C (P<0. 01),but there was no significant difference in the level of HDL-C between the two groups. Conclusion Huazhuo Tongmai Powder can decrease serum lipids and the expression of IL-1. It can protect artery intima and prevent arteriosclerosis obliterans.