临床肿瘤学杂志
臨床腫瘤學雜誌
림상종류학잡지
CHINESE CLINICAL ONCOLOGY
2014年
10期
929-931
,共3页
宫颈癌%放射治疗%化学治疗%紫杉醇脂质体%奈达铂
宮頸癌%放射治療%化學治療%紫杉醇脂質體%奈達鉑
궁경암%방사치료%화학치료%자삼순지질체%내체박
Cervical cancer%Radiotherapy%Chemotherapy%Paclitaxel liposome%Nedaplatin
目的:比较紫杉醇脂质体联合奈达铂同步放疗与氟尿嘧啶联合奈达铂同步放疗治疗中晚期宫颈癌的疗效和不良反应。方法回顾性分析2010年5月至2012年5月收治的中晚期宫颈癌患者58例,分为紫杉醇脂质体联合奈达铂组( A组,n=30)和氟尿嘧啶联合奈达铂组( B组,n=28)。两组同步放疗均为盆腔三维适形放疗加后装放疗,保证A点总剂量70~85Gy,B点总剂量50Gy。两组患者在放疗第1天同步进行化疗。 A组:紫杉醇脂质体135mg/m2静滴,d1;奈达铂80mg/m2静滴,d1;B组:氟尿嘧啶500mg/m2静滴,d1~d5;奈达铂80mg/m2静滴,d1。两组化疗均21~28天为1周期,化疗2个周期。结果全部患者均按计划完成治疗。 A组的有效率为76.7%( CR 13例,PR 10例,SD 6例,PD 1例),B组为57.1%( CR 9例, PR 7例,SD 7例,PD 5例),两组差异有统计学意义(P<0.05)。 A组1、2年生存率分别为100%和92%,B组分别为88%和75%,两组差异有统计学意义( P<0.05)。两组不良反应主要为骨髓抑制和消化道反应,A组的不良反应发生率低于B组,差异有统计学意义( P<0.05)。结论紫杉醇脂质体联合奈达铂同步放疗治疗中晚期宫颈癌疗效确切,不良反应轻,值得临床推广应用。
目的:比較紫杉醇脂質體聯閤奈達鉑同步放療與氟尿嘧啶聯閤奈達鉑同步放療治療中晚期宮頸癌的療效和不良反應。方法迴顧性分析2010年5月至2012年5月收治的中晚期宮頸癌患者58例,分為紫杉醇脂質體聯閤奈達鉑組( A組,n=30)和氟尿嘧啶聯閤奈達鉑組( B組,n=28)。兩組同步放療均為盆腔三維適形放療加後裝放療,保證A點總劑量70~85Gy,B點總劑量50Gy。兩組患者在放療第1天同步進行化療。 A組:紫杉醇脂質體135mg/m2靜滴,d1;奈達鉑80mg/m2靜滴,d1;B組:氟尿嘧啶500mg/m2靜滴,d1~d5;奈達鉑80mg/m2靜滴,d1。兩組化療均21~28天為1週期,化療2箇週期。結果全部患者均按計劃完成治療。 A組的有效率為76.7%( CR 13例,PR 10例,SD 6例,PD 1例),B組為57.1%( CR 9例, PR 7例,SD 7例,PD 5例),兩組差異有統計學意義(P<0.05)。 A組1、2年生存率分彆為100%和92%,B組分彆為88%和75%,兩組差異有統計學意義( P<0.05)。兩組不良反應主要為骨髓抑製和消化道反應,A組的不良反應髮生率低于B組,差異有統計學意義( P<0.05)。結論紫杉醇脂質體聯閤奈達鉑同步放療治療中晚期宮頸癌療效確切,不良反應輕,值得臨床推廣應用。
목적:비교자삼순지질체연합내체박동보방료여불뇨밀정연합내체박동보방료치료중만기궁경암적료효화불량반응。방법회고성분석2010년5월지2012년5월수치적중만기궁경암환자58례,분위자삼순지질체연합내체박조( A조,n=30)화불뇨밀정연합내체박조( B조,n=28)。량조동보방료균위분강삼유괄형방료가후장방료,보증A점총제량70~85Gy,B점총제량50Gy。량조환자재방료제1천동보진행화료。 A조:자삼순지질체135mg/m2정적,d1;내체박80mg/m2정적,d1;B조:불뇨밀정500mg/m2정적,d1~d5;내체박80mg/m2정적,d1。량조화료균21~28천위1주기,화료2개주기。결과전부환자균안계화완성치료。 A조적유효솔위76.7%( CR 13례,PR 10례,SD 6례,PD 1례),B조위57.1%( CR 9례, PR 7례,SD 7례,PD 5례),량조차이유통계학의의(P<0.05)。 A조1、2년생존솔분별위100%화92%,B조분별위88%화75%,량조차이유통계학의의( P<0.05)。량조불량반응주요위골수억제화소화도반응,A조적불량반응발생솔저우B조,차이유통계학의의( P<0.05)。결론자삼순지질체연합내체박동보방료치료중만기궁경암료효학절,불량반응경,치득림상추엄응용。
Objective To compare the effect and adverse reaction of paclitaxel liposome and nedaplatin combined with radio-therapy versus fluorouracil and nedaplatin combined with radiotherapy in advanced cervical cancer. Methods A retrospective analysis of 58 cases of advanced cervical cancer patients from May 2010 to May 2012 was made. Fifty-eight patients were divided into paclitaxel liposome and nedaplatin combined with radiotherapy group ( A group, n=30) , and the other 28 cases were treated by fluorouracil and nedaplatin combined with radiotherapy ( B group, n=28) . The radiotherapy included pelvis three-dimensional conformal radiotherapy plus brachytherapy, and the total dose of A point was 70-85Gy, while the B point was 50Gy. Chemotherapy was applied at the first day of radiotherapy. Paclitaxel liposome and nedaplatin regimen was given as follows: paclitaxel liposome 135mg/m2 iv d1 , nedaplatin 80mg/m2 iv d1 . Fluorouracil and nedaplatin regimen was applied as follows: fluorouracil 500mg/m2 iv d1-d5 , nedaplatin 80mg/m2 iv d1 . For both regimens, 21-28 days was a cycle with a total of 2 cycles. Results The treatment was completed in both groups. The ef-fective rate of A group was 76. 7% ( CR 13,PR 10,SD 6,PD 1) , and it of B group was 57. 1%( CR 9,PR 7,SD 7,PD 5) with statisti-cal difference( P<0. 05) . The 1-,2-year survival rates of A group were 100% and 92%, and the rates in B group were 88% and 75%, with statistical difference( P<0. 05) . The main adverse reactions in the two groups were myelosuppression and digestive tract reaction. The occurrence of adverse reactions in A group was lower than B group, and the difference was statistically significant (P<0. 05). Conclusion The curative effect of clinical application of paclitaxel liposome and nedaplatin combined with radiotherapy in the treat-ment of advanced cervical cancer is satisfied with tolerable adverse reactions. It is worth of clinical application.