CAJ | 학술논문

目的：研究尿毒症继发重症甲状旁腺功能亢进症（ secondary hyperparathyroidism，SHPT）患者肺功能损害特征及其可能的相关因素。方法应用肺功能仪检测40例重症SHPT患者的肺功能，30例同期不伴有严重SHPT的维持性血透（ maintenance hemodialysis， MHD）患者及30例健康体检者作为对照组，并就SHPT组肺功能指标与全段甲状旁腺激素（ intact parathyroid hormone， iPTH）等临床检验指标做相关性分析。结果 SHPT组和MHD组较健康体检者、SHPT组较MHD组肺功能均明显下降（P＜0．05）。 SHPT组患者肺功能多项指标与血iPTH、C反应蛋白（C reactive protein，CRP）、透析龄（dialysis age）呈负相关（P＜0．05），与血红蛋白（hemoglobin， Hb）、白蛋白（albu-min， Alb）呈正相关（P＜0．05）。结论重症SHPT患者肺功能明显异常。血iPTH、透析龄、血红蛋白、白蛋白及CRP可能是影响SHPT患者肺功能的重要因素。
목적：연구뇨독증계발중증갑상방선공능항진증（ secondary hyperparathyroidism，SHPT）환자폐공능손해특정급기가능적상관인소。방법응용폐공능의검측40례중증SHPT환자적폐공능，30례동기불반유엄중SHPT적유지성혈투（ maintenance hemodialysis， MHD）환자급30례건강체검자작위대조조，병취SHPT조폐공능지표여전단갑상방선격소（ intact parathyroid hormone， iPTH）등림상검험지표주상관성분석。결과 SHPT조화MHD조교건강체검자、SHPT조교MHD조폐공능균명현하강（P＜0．05）。 SHPT조환자폐공능다항지표여혈iPTH、C반응단백（C reactive protein，CRP）、투석령（dialysis age）정부상관（P＜0．05），여혈홍단백（hemoglobin， Hb）、백단백（albu-min， Alb）정정상관（P＜0．05）。결론중증SHPT환자폐공능명현이상。혈iPTH、투석령、혈홍단백、백단백급CRP가능시영향SHPT환자폐공능적중요인소。
Objectives To evaluate the lung function in patients of severe secondary hyperparathyroidism caused by uremia and to analyze related factors.Methods The pulmonary function of 70 patients with uremia ( 40 patients with severe secondary hyperparathyroidism, 30 MHD patients without SHPT) and 30 healthy people was determined.Correlative analysis was performed between parameters such as pulmonary function indexes and clinical or laboratory parameters. Results Lung function was significantly different between patients with uremia and healthy subjects(P<0.05, respectively). A number of lung function indicators were negatively correlated with iPTH,C reactive protein( CRP) ,dialysis age but were positively correlated with hemoglobin (Hb) and albumin(Alb) (P <0.05).Conclusion Patients with SHPT show impaired lung function.IPTH, dialysis age, Hb, Alb and CRP can be used as important indicators of lung function.