临床肿瘤学杂志
臨床腫瘤學雜誌
림상종류학잡지
CHINESE CLINICAL ONCOLOGY
2014年
10期
901-905
,共5页
胃癌%核转录共抑制因子%早期生长反应基因3%分泌型卷曲相关蛋白1
胃癌%覈轉錄共抑製因子%早期生長反應基因3%分泌型捲麯相關蛋白1
위암%핵전록공억제인자%조기생장반응기인3%분비형권곡상관단백1
Gastric cancer%Ski-novel protein( SnoN)%Early growth response protein 3( Egr3)%Secreted frizzled relat-ed protein 1( SFRP1)
目的：探讨核转录共抑制因子SnoN、早期生长反应基因3（ Egr3）和分泌型卷曲相关蛋白1（ SFRP1）在胃癌组织中的表达水平，分析三者与胃癌临床病理特征的关系。方法收集75例胃癌组织及62例癌旁组织标本，采用免疫组化Elivision法检测以上组织石蜡切片中SnoN、Egr3及SFRP1的表达情况，分析3种蛋白表达与胃癌临床病理特征的关系。结果胃癌组织中SnoN、SFRP1的高表达率为45．3％（34/75）和38．7％（29/75），均低于癌旁组织的62．9％（39/62）和58．1％（36/62）；而Egr3的高表达率为69．3％（52/75），高于癌旁组织的38．7％（24/62）。以上差异均有统计学意义（P＜0．05）。 SnoN、Egr3和SFRP1的表达均与临床分期、分化程度有关，SnoN表达还与年龄、浸润深度及淋巴结转移有关，SFRP1表达与年龄、肿瘤大小及浸润深度有关。 SnoN、SFRP1与Egr3的表达均呈负相关，相关系数依次为r＝-0．324、-0．244（ P均＜0．05）；SnoN与SFRP1的表达呈正相关（ r＝0．487， P＜0．001）。结论胃癌组织中SnoN、SFRP1呈低表达，而Egr3呈高表达，三者表达均与临床分期、分化程度有关，提示三者在胃癌发生、发展中有重要意义，可用于辅助胃癌的诊断和病情评估。
目的：探討覈轉錄共抑製因子SnoN、早期生長反應基因3（ Egr3）和分泌型捲麯相關蛋白1（ SFRP1）在胃癌組織中的錶達水平，分析三者與胃癌臨床病理特徵的關繫。方法收集75例胃癌組織及62例癌徬組織標本，採用免疫組化Elivision法檢測以上組織石蠟切片中SnoN、Egr3及SFRP1的錶達情況，分析3種蛋白錶達與胃癌臨床病理特徵的關繫。結果胃癌組織中SnoN、SFRP1的高錶達率為45．3％（34/75）和38．7％（29/75），均低于癌徬組織的62．9％（39/62）和58．1％（36/62）；而Egr3的高錶達率為69．3％（52/75），高于癌徬組織的38．7％（24/62）。以上差異均有統計學意義（P＜0．05）。 SnoN、Egr3和SFRP1的錶達均與臨床分期、分化程度有關，SnoN錶達還與年齡、浸潤深度及淋巴結轉移有關，SFRP1錶達與年齡、腫瘤大小及浸潤深度有關。 SnoN、SFRP1與Egr3的錶達均呈負相關，相關繫數依次為r＝-0．324、-0．244（ P均＜0．05）；SnoN與SFRP1的錶達呈正相關（ r＝0．487， P＜0．001）。結論胃癌組織中SnoN、SFRP1呈低錶達，而Egr3呈高錶達，三者錶達均與臨床分期、分化程度有關，提示三者在胃癌髮生、髮展中有重要意義，可用于輔助胃癌的診斷和病情評估。
목적：탐토핵전록공억제인자SnoN、조기생장반응기인3（ Egr3）화분비형권곡상관단백1（ SFRP1）재위암조직중적표체수평，분석삼자여위암림상병리특정적관계。방법수집75례위암조직급62례암방조직표본，채용면역조화Elivision법검측이상조직석사절편중SnoN、Egr3급SFRP1적표체정황，분석3충단백표체여위암림상병리특정적관계。결과위암조직중SnoN、SFRP1적고표체솔위45．3％（34/75）화38．7％（29/75），균저우암방조직적62．9％（39/62）화58．1％（36/62）；이Egr3적고표체솔위69．3％（52/75），고우암방조직적38．7％（24/62）。이상차이균유통계학의의（P＜0．05）。 SnoN、Egr3화SFRP1적표체균여림상분기、분화정도유관，SnoN표체환여년령、침윤심도급림파결전이유관，SFRP1표체여년령、종류대소급침윤심도유관。 SnoN、SFRP1여Egr3적표체균정부상관，상관계수의차위r＝-0．324、-0．244（ P균＜0．05）；SnoN여SFRP1적표체정정상관（ r＝0．487， P＜0．001）。결론위암조직중SnoN、SFRP1정저표체，이Egr3정고표체，삼자표체균여림상분기、분화정도유관，제시삼자재위암발생、발전중유중요의의，가용우보조위암적진단화병정평고。
Objective To explore the expressions of Ski-novel protein ( SnoN) , early growth response protein 3 ( Egr3) and secreted frizzled related protein 1( SFRP1) in gastric cancer tissue, and further analyze their clinicopathological characteristics in gas-tric cancer. Methods Seventy-five cases of gastric cancer tissues and 62 cases of para-cancer tissues were collected. The immunohis-tochemical Elivision method was used to analyze the expressions of SnoN, Egr3 and SFRP1 from the above tissues. The clinicopatholog-ical characteristics of gastric cancer patients were collected and subsequently analyzed for their correlation with expressions of SnoN, Egr3 and SFRP1. Results The high-level expression rates of SnoN and SFRP1 were 45. 3%(34/75) and 38. 7%(29/75), both lower than 62. 9%( 39/62) and 58. 1%( 36/62) in para-cancer tissues ( P<0. 05) . While the high-level expression rate of Egr3 was 69. 3%(52/75) in cancer tissues, higher than 38. 7%(24/62) in para-cancer tissues (P<0. 05). The expression of SnoN, Egr3 and SFRP1 were related with clinical stage and degree of differentiation. In addition, the SnoN expression was related with age, depth of invasion and lymph node metastasis, and SFRP1 expression was related with age, tumor size and depth of invasion. The expressions of both SnoN and SFRP1 were all negatively correlated with Egr3 in cancer tissues ( r=-0. 324,-0. 244) with significant difference ( P<0. 05) . The SnoN expression was positively correlated with SFRP1( r=0. 487, P<0. 001) . Conclusion There are high expression of Egr3 but low expression of SnoN and SFRP1 in gastric cancer. All tested proteins are related with clinical stage and degree of differenti-ation, indicating an important role in the occurrence and development of gastric cancer.
