CAJ | 학술논문

目的：考察社会隔离饲养大鼠模拟精神分裂症等神经发育性精神疾病的行为表征变化。方法自断乳起单笼饲养雄性大鼠幼仔至成年，依次进行自发活动检测、Morris水迷宫实验和社会交往实验。结果与对照比较，社会隔离饲养的大鼠表现出体质量增加、自发活动亢进以及社会交往增多等行为学改变，但在Morris水迷宫实验中没有表现出空间学习记忆的明显变化。结论大鼠幼年时的社会隔离饲养对动物成年后的行为产生深刻影响，可用来建立精神分裂症等神经发育性精神疾病的动物模型。
목적：고찰사회격리사양대서모의정신분렬증등신경발육성정신질병적행위표정변화。방법자단유기단롱사양웅성대서유자지성년，의차진행자발활동검측、Morris수미궁실험화사회교왕실험。결과여대조비교，사회격리사양적대서표현출체질량증가、자발활동항진이급사회교왕증다등행위학개변，단재Morris수미궁실험중몰유표현출공간학습기억적명현변화。결론대서유년시적사회격리사양대동물성년후적행위산생심각영향，가용래건립정신분렬증등신경발육성정신질병적동물모형。
Objective To investigate rats reared in social isolation as a model of behavioral symptoms of neurodevelop-mental psychiatric disorders including schizophrenia.Methods Male rat pups were housed in individual cages from post-weaning to adulthood.Locomotor activity detection, Morris water maze test and social interaction test were performed. Results Compared with controls, the social isolation-reared rats got more body mass, showed locomotor hyperactivity and increased social interaction, but significant spatial learning changes were not observed in Morris water maze test.Conclu-sion Exposing rats to social isolation can profoundly affect behavior in adulthood, which can be used to build animal mod-els of neurodevelopmental psychiatric disorders including schizophrenia.