CAJ | 학술논문

目的：研究高原驻训部队返回人员炎症因子失衡的变化及其意义。方法对21名长期居住平原地区（海拔200 m），平均25岁，初上高原前身体健康，驻训6个月返回后出现高原脱适应症的男性官兵，在上高原前（Control）、返回平原第2天（d2）及第30天（d30）分别抽取空腹静脉血，分离血清，-80℃冻存，ELISA法检测上述返回人员血清中IL-17A及IL-10的含量。结果 d2及d30时间点IL-17A含量及IL-17A/IL-10比率较Control有显著增高（P＜0．05），d30时间点IL-17A含量及IL-17A/IL-10比率低于d2时间点（P＜0．05）；d2及d30时间点IL-10的含量较Control有显著降低（P＜0．05），但d30时间点IL-10含量高于d2时间点（P＜0．05）。在Control、d2、d30时间点IL-10与IL-17A存在呈正相关（r1＝0．948， P＜0．05；r2＝0．969， P＜0．05；r3＝0．972， P＜0．05）；IL-10与IL-17A在d2与Control间、d30与d2间的改变量呈负相关（ r4＝-0．793， P＜0．05；r5＝-0．756， P＜0．05）。结论高原驻训部队返回人员机体中存在炎症因子失衡的现象，其程度随着返回平原时间的延长而减弱，其炎症因子失衡有所恢复，但其具体机制仍需进一步研究。
목적：연구고원주훈부대반회인원염증인자실형적변화급기의의。방법대21명장기거주평원지구（해발200 m），평균25세，초상고원전신체건강，주훈6개월반회후출현고원탈괄응증적남성관병，재상고원전（Control）、반회평원제2천（d2）급제30천（d30）분별추취공복정맥혈，분리혈청，-80℃동존，ELISA법검측상술반회인원혈청중IL-17A급IL-10적함량。결과 d2급d30시간점IL-17A함량급IL-17A/IL-10비솔교Control유현저증고（P＜0．05），d30시간점IL-17A함량급IL-17A/IL-10비솔저우d2시간점（P＜0．05）；d2급d30시간점IL-10적함량교Control유현저강저（P＜0．05），단d30시간점IL-10함량고우d2시간점（P＜0．05）。재Control、d2、d30시간점IL-10여IL-17A존재정정상관（r1＝0．948， P＜0．05；r2＝0．969， P＜0．05；r3＝0．972， P＜0．05）；IL-10여IL-17A재d2여Control간、d30여d2간적개변량정부상관（ r4＝-0．793， P＜0．05；r5＝-0．756， P＜0．05）。결론고원주훈부대반회인원궤체중존재염증인자실형적현상，기정도수착반회평원시간적연장이감약，기염증인자실형유소회복，단기구체궤제잉수진일보연구。
Objective To analyze the change in the concentration of IL-17 and IL-10 inflammatory factors among the deadaptation personnel who returned from the plateau.Methods A total 21 healthy males were investigated who averaged 25 years in age, lived permanently in the plains (200 m), and once stayed to the plateau (Lasha) for 6 months.Their venous blood was collected at three time points:the day before ascending to the plateau(control), the second day after return to the plains(d2) and the 30th day(d30), respectively.Their serum was seperated from the whole blood and the level of IL-17A and IL-10 was detected by ELISA method.Results The concentration of IL-17A and the IL-17A/IL-10 ratio were significant increased at d2 and d30, respectively, compared with control (P<0.05).Compared with d2, IL-17A and the IL-17A/IL-10 ratio were decreased obviously at d30(P <0.05).The level of IL-10 at d2 and d30 was significantly reduced compared with control ( P <0.05), but increased at d30 compared with d2.Correlative analysis showed that there was a negative correlation in the levels of IL-10 and IL-17A between control, d2 and d30, respectively (r1=0.948, P<0.05;r2=0.969, P<0.05;r3=0.972, P<0.05).A significant negative correlation was observed in the alteration levels of IL-10 and IL-17A between the three groups(r4=-0.793, P<0.05; r5=-0.756, P<0.05). Conclusion The concentration of inflammatory factors among the plateau deadaptation patients is imbalanced, but it is gradually reduced with time.The mechanism is still not clear.