CAJ | 학술논문

目的：探讨根据联合检测血栓弹力图和CYP2C19基因分型的结果优化冠状动脉左主干支架植入术后应用抗血小板药物治疗的临床效果。方法98例左主干支架术植入术后患，联合检测血栓弹力图和 CYP2C19基因分型，根据结果分为3组，合格组、常规剂量治疗组、大剂量治疗组，随访6个月记录患者的主要心脏不良事件（ MACE）发生情况。结果随访6个月共发生主要心脏不良事件13例，其中合格组6例（11.7％），常规治疗组4例（16.0％），大剂量治疗组3例（13.6％），3组中常规剂量治疗组的不良事件发生率大于大剂量治疗组，大剂量治疗组大于合格组，差异有统计学意义（P＜0.05）。结论联合检测弹力图和CYP2C19基因分型在优化左主干支架植入术后应用抗血小板药物治疗具有一定的指导意义。
목적：탐토근거연합검측혈전탄력도화CYP2C19기인분형적결과우화관상동맥좌주간지가식입술후응용항혈소판약물치료적림상효과。방법98례좌주간지가술식입술후환，연합검측혈전탄력도화 CYP2C19기인분형，근거결과분위3조，합격조、상규제량치료조、대제량치료조，수방6개월기록환자적주요심장불량사건（ MACE）발생정황。결과수방6개월공발생주요심장불량사건13례，기중합격조6례（11.7％），상규치료조4례（16.0％），대제량치료조3례（13.6％），3조중상규제량치료조적불량사건발생솔대우대제량치료조，대제량치료조대우합격조，차이유통계학의의（P＜0.05）。결론연합검측탄력도화CYP2C19기인분형재우화좌주간지가식입술후응용항혈소판약물치료구유일정적지도의의。
OBJECTIVE To investigate the clinical effect of antiplatelet therapy according to the joint detection thrombelastograph and CYP 2 C19 genotype results after left main coronary artery stent implantation.METHODS 98 patients were divided into three groups:qualified group ,conventional dose treatment group ,high-dose treatment group after left main artery stent implantation , according to the result of joint detection thrombelastograph and CYP 2C19 genotype.The major adverse cardiac events ( MACE) of patients after followed up for 6 months.RESULTS A total of 13 cases of major adverse cardiac events ,including qualified group of 6 cases (11.7%),4 cases (16.0%) and conventional treatment group high-dose treatment group 3 cases (13.6%) After followed up for 6 months.The inci-dence of adverse events than high-dose treatment group ,high-dose treatment group is more than qualified group ,the difference was statistically significant ( P <0.05 ).CONCLUSION Joint detection thrombelastograph and CYP2C19 genotype has a certain guiding significance in the optimization of antiplatelet therapy after left main artery stent implantation.