CAJ | 학술논문

目的：采用冷冻干燥法制备缬沙坦（Valsartan）速释固体分散体（SD）来提高其体外溶出度。方法分别以羟丙甲基纤维素（HPMC）、聚乙二醇6000（PEG 6000）、聚乙烯吡咯烷酮k30（PVPk30）为载体，十二烷基硫酸钠（SDS）为表面活性剂来制备不同比例的缬沙坦固体分散体，通过测定体外溶出度，来选择最优辅料及比例，结果当以PEG 6000为载体，SDS为表面活性剂时，且药物∶PEG 6000∶SDS＝1∶5∶1％时药物呈现了很好的水溶性。结论在5min时即可溶出90％以上，很大程度上提高了缬沙坦的体外溶出度。
목적：채용냉동간조법제비힐사탄（Valsartan）속석고체분산체（SD）래제고기체외용출도。방법분별이간병갑기섬유소（HPMC）、취을이순6000（PEG 6000）、취을희필각완동k30（PVPk30）위재체，십이완기류산납（SDS）위표면활성제래제비불동비례적힐사탄고체분산체，통과측정체외용출도，래선택최우보료급비례，결과당이PEG 6000위재체，SDS위표면활성제시，차약물∶PEG 6000∶SDS＝1∶5∶1％시약물정현료흔호적수용성。결론재5min시즉가용출90％이상，흔대정도상제고료힐사탄적체외용출도。
OBJECTIVE Prepare the solid dispersions of valsartan by the freeze-drying method to enhance the dissolution rate of the drug.METHODS The solid dispersions of valsartan have been prepared with HPMC , PEG 6000 ,PVPk30 and SDS, respectively.Then chose the optimal materials and the ratio by the dissolution rate da-ta.CONCLUSION The dissolution rate improved to the 90%at 5min,when used PEG 6000 as the carriers,SDS as the surfactant and the ratio of drug∶PEG 6000∶SDS was 1∶5∶1% in the solid dispersion system.The dissolution rate of the drug have been increased significantly.