海峡药学
海峽藥學
해협약학
STRAIT PHARMACEUTICAL JOURNAL
2014年
10期
9-11,12
,共4页
正交设计%分散片%崩解度%绿原酸%黄芩苷
正交設計%分散片%崩解度%綠原痠%黃芩苷
정교설계%분산편%붕해도%록원산%황금감
Orthogonal design%Dispersible tablets%Disintegration
目的：利用正交设计筛选出银黄分散片的最佳处方。方法通过调节崩解剂的含量，粘合剂的浓度等因素，制备银黄分散片，考察崩解时限，混悬性等因素，对处方进行筛选。结果优选处方为A1 B3 C1。即：微晶纤维素含量为8％，CMS-Na含量为15％，聚乙烯吡咯烷酮K30浓度为5％。对优选处方的实验表明：崩解时间小于3min，分散均匀性试验能通过2号筛网，混悬性较好。结论本方法简单，可靠，优选处方的银黄分散片达到中国药典要求。
目的：利用正交設計篩選齣銀黃分散片的最佳處方。方法通過調節崩解劑的含量，粘閤劑的濃度等因素，製備銀黃分散片，攷察崩解時限，混懸性等因素，對處方進行篩選。結果優選處方為A1 B3 C1。即：微晶纖維素含量為8％，CMS-Na含量為15％，聚乙烯吡咯烷酮K30濃度為5％。對優選處方的實驗錶明：崩解時間小于3min，分散均勻性試驗能通過2號篩網，混懸性較好。結論本方法簡單，可靠，優選處方的銀黃分散片達到中國藥典要求。
목적：이용정교설계사선출은황분산편적최가처방。방법통과조절붕해제적함량，점합제적농도등인소，제비은황분산편，고찰붕해시한，혼현성등인소，대처방진행사선。결과우선처방위A1 B3 C1。즉：미정섬유소함량위8％，CMS-Na함량위15％，취을희필각완동K30농도위5％。대우선처방적실험표명：붕해시간소우3min，분산균균성시험능통과2호사망，혼현성교호。결론본방법간단，가고，우선처방적은황분산편체도중국약전요구。
OBJECTIVE To screen the optimum formula for Yinhuang dispersible tablets by orthogonal de-sign.METHODS Yinhuang dispersible tablets was prepared by adjusting the content of disintogrant and the uncen -tration of adhesive.The disintegration Time and suspension were inspected to select .RESULTS The optimized for-mula was A1 B3 C1.The percentage of Microcrystalline CE and CMS-Na were 8%and 15%respectively,and the con-centration of PVP30 was 5%.The disintegration time was less than 3min, and it could pass through a No.2 sieve.CONCLUSION This method is simple and reliable ,and the formula optimization of the Yinhuang dispersed tablets reached the standard listed in Ch.P 2005 edition.
