CAJ | 학술논문

目的：探讨微小RNA( miRNA)-143在非小细胞肺癌( NSCLC)组织中的表达水平及其与临床病理特征之间的关系。方法：选取40例NSCLC组织及其癌旁组织，采用实时荧光定量聚合酶链反应技术检测miRNA-143的表达水平，并分析其与临床病理特征之间的关系。结果：miRNA-143在NSCLC组织中的表达水平低于癌旁组织(P<0.05)；miRNA-143的表达在不同年龄、性别、组织学类型、分化程度、TNM 分期间的差异均无统计学意义(P >0.05)。 NSCLC 伴淋巴结转移的肺癌组织中miRNA-143的表达水平低于NSCLC不伴淋巴结转移的肺癌组织(P<0.05)。结论：miRNA-143在NSCLC组织中表达下调，且可能与肺癌细胞的转移有关。
목적：탐토미소RNA( miRNA)-143재비소세포폐암( NSCLC)조직중적표체수평급기여림상병리특정지간적관계。방법：선취40례NSCLC조직급기암방조직，채용실시형광정량취합매련반응기술검측miRNA-143적표체수평，병분석기여림상병리특정지간적관계。결과：miRNA-143재NSCLC조직중적표체수평저우암방조직(P<0.05)；miRNA-143적표체재불동년령、성별、조직학류형、분화정도、TNM 분기간적차이균무통계학의의(P >0.05)。 NSCLC 반림파결전이적폐암조직중miRNA-143적표체수평저우NSCLC불반림파결전이적폐암조직(P<0.05)。결론：miRNA-143재NSCLC조직중표체하조，차가능여폐암세포적전이유관。
Objective:To explore the expression of micro RNA(miRNA)-143 in non-small cell lung cancer(NSCLC) tissue and relationship with clinicopathological features of tissue. Methods:The expression levels of miRNA-143 in NSCLC and adjacent cancerous tissue of 40 cases were detected by real-time PCR. The relationship of miRNA-143 expression with clinicopathological features of tissue was analyzed. Results:The expression of miRNA-143 in NSCLC tissue was significantly lower than that in adjacent cancerous tissue (P<0. 05). The expression differences of miRNA-143 in different ages,gender,histologic types,differentiation degrees and TNM stages were not statistical significance(P>0. 05). The expression level of miRNA-143 in NSCLC tissue with lymph node metastasis was lower than that in NSCLC tissue without lymph node metastasis(P<0. 05). Conclusions:The expression level of miRNA-143 in NSCLC tissue decreases,which may be correlated with the cell metastasis of lung cancer.