蚌埠医学院学报
蚌埠醫學院學報
방부의학원학보
ACTA ACADEMIAE MEDICINAE BENGBU
2014年
10期
1327-1329
,共3页
张二春%彭钧%熊若华%慈思慧
張二春%彭鈞%熊若華%慈思慧
장이춘%팽균%웅약화%자사혜
宫颈肿瘤%Survivin基因%原位杂交表达%癌前病变
宮頸腫瘤%Survivin基因%原位雜交錶達%癌前病變
궁경종류%Survivin기인%원위잡교표체%암전병변
cervical neoplasms%Survivin gene%situ hybridization expression%precancerous lesions
目的：探讨Survivin原位杂交表达在宫颈癌及癌前病变诊断中的应用效果。方法：选取45例宫颈癌患者病理组织为观察组，宫颈上皮内瘤变组织45例为对照1组，正常宫颈组织45例为对照2组。入试者均行Survivin原位杂交检测。结果：Survivin在对照2组、对照1组、观察组阳性率分别为2.2%、48.9%和84.4%，差异均有统计学意义(P<0.01)。 Survivin在宫颈癌Ⅰ期、Ⅱ期和Ⅲ期中的阳性率，在宫颈癌高分化组、中分化组及低分化组中的阳性率和在宫颈癌伴淋巴结转移组与不伴淋巴结转移组中阳性率差异均无统计学意义(P>0.05)。结论：Suvrvini在宫颈癌及癌前病变的发生发展中发挥一定作用，可作为宫颈癌预后不良的标志之一。
目的：探討Survivin原位雜交錶達在宮頸癌及癌前病變診斷中的應用效果。方法：選取45例宮頸癌患者病理組織為觀察組，宮頸上皮內瘤變組織45例為對照1組，正常宮頸組織45例為對照2組。入試者均行Survivin原位雜交檢測。結果：Survivin在對照2組、對照1組、觀察組暘性率分彆為2.2%、48.9%和84.4%，差異均有統計學意義(P<0.01)。 Survivin在宮頸癌Ⅰ期、Ⅱ期和Ⅲ期中的暘性率，在宮頸癌高分化組、中分化組及低分化組中的暘性率和在宮頸癌伴淋巴結轉移組與不伴淋巴結轉移組中暘性率差異均無統計學意義(P>0.05)。結論：Suvrvini在宮頸癌及癌前病變的髮生髮展中髮揮一定作用，可作為宮頸癌預後不良的標誌之一。
목적：탐토Survivin원위잡교표체재궁경암급암전병변진단중적응용효과。방법：선취45례궁경암환자병리조직위관찰조，궁경상피내류변조직45례위대조1조，정상궁경조직45례위대조2조。입시자균행Survivin원위잡교검측。결과：Survivin재대조2조、대조1조、관찰조양성솔분별위2.2%、48.9%화84.4%，차이균유통계학의의(P<0.01)。 Survivin재궁경암Ⅰ기、Ⅱ기화Ⅲ기중적양성솔，재궁경암고분화조、중분화조급저분화조중적양성솔화재궁경암반림파결전이조여불반림파결전이조중양성솔차이균무통계학의의(P>0.05)。결론：Suvrvini재궁경암급암전병변적발생발전중발휘일정작용，가작위궁경암예후불량적표지지일。
Objective:To investigate the application value of Survivin expression in the diagnosis of cervical cancer and precancerous lesions by in situ hybridization. Methods:The Survivin expressions in 45 tissue samples of cervical cancer ( observation group ) , 45 tissue samples of cervical intraepithelial neoplasia(control group 1) and 45 normal cervical tissue samples(control group 2) were detected by in situ hybridization. Results:The positive rates of Survivin expression in control group 2,control 1 group and observation group were 2. 2%,48. 9% and 84. 4%,respectively,the differences of which were statistically significant(P<0. 01). The differences of positive rate of Survivin expression in the patients with stageⅠ,II and Ⅲ cervical cancer, high, moderate and low differentiation cervical cancer and cervical cancer complicated with and without lymph node metastasis were not statistically significant(P>0. 05). Conclusions:Survivin plays certain role in the occurrence and development of cervical cancer and precancerous lesions,which can be used as a sign of poor prognosis.
