新疆医科大学学报
新疆醫科大學學報
신강의과대학학보
JOURNAL OF XINJIANG MEDICAL UNIVERSITY
2014年
11期
1441-1446
,共6页
吴燕%巴吐尔·买买提明%李威%高振%哈木拉提·吾甫尔
吳燕%巴吐爾·買買提明%李威%高振%哈木拉提·吾甫爾
오연%파토이·매매제명%리위%고진%합목랍제·오보이
异常黑胆质%支气管哮喘%代谢组学%核磁共振
異常黑膽質%支氣管哮喘%代謝組學%覈磁共振
이상흑담질%지기관효천%대사조학%핵자공진
abnormal savda syndrome%bronchial asthma%metabonomics%NMR
目的:揭示支气管哮喘患者异常黑胆质型与非异常黑胆质型的血浆代谢组变化情况及发生机制。方法对61例异常黑胆质型支气管哮喘患者和55名非异常黑胆质型支气管哮喘患者的血浆进行核磁共振氢谱检测,通过谱图分段积分后运用正交偏最小二乘判别分析法(OPLS-DA)分析所采集的图谱。结果异常黑胆质型哮喘患者与健康对照组相比,血浆中异亮氨酸、亮氨酸、丙氨酸、缬氨酸、酪氨酸、甘氨酸等氨基酸以及谷氨酰胺、α-葡萄糖、β-葡萄糖、糖蛋白、肌酸、乳酸、肉碱、丙酮、丙酮酸、脂类[包含低密度脂蛋白(LDL)和极低密度脂蛋白(VLDL)]、不饱和脂类的含量均有不同程度的降低(P <0.05)。与非异常黑胆质型哮喘患者相比,异常黑胆质型哮喘患者血浆中α-葡萄糖、β-葡萄糖、糖蛋白明显升高(P <0.05),丙氨酸、谷氨酸、缬氨酸、亮氨酸、异亮氨酸、甘氨酸、酪氨酸、苯丙氨酸、1-甲基组氨酸等多种氨基酸含量升高,乙酰乙酸、丙酮,丙酮酸、乳酸、肌酸、肌酸酐、肉碱等代谢物含量升高,LDL 和 VLDL、不饱和脂类、乙酸、乙酰半胱氨酸、谷氨酰胺、鲨肌醇等化合物含量升高(P <0.05)。结论异常黑胆质型哮喘患者体内能量代谢和蛋白质代谢发生改变,体内糖异生和免疫功能的紊乱程度较严重,这可能是异常黑胆质型哮喘形成的生物学基础之一,也从一个侧面证实维医“同病异证”的科学性。
目的:揭示支氣管哮喘患者異常黑膽質型與非異常黑膽質型的血漿代謝組變化情況及髮生機製。方法對61例異常黑膽質型支氣管哮喘患者和55名非異常黑膽質型支氣管哮喘患者的血漿進行覈磁共振氫譜檢測,通過譜圖分段積分後運用正交偏最小二乘判彆分析法(OPLS-DA)分析所採集的圖譜。結果異常黑膽質型哮喘患者與健康對照組相比,血漿中異亮氨痠、亮氨痠、丙氨痠、纈氨痠、酪氨痠、甘氨痠等氨基痠以及穀氨酰胺、α-葡萄糖、β-葡萄糖、糖蛋白、肌痠、乳痠、肉堿、丙酮、丙酮痠、脂類[包含低密度脂蛋白(LDL)和極低密度脂蛋白(VLDL)]、不飽和脂類的含量均有不同程度的降低(P <0.05)。與非異常黑膽質型哮喘患者相比,異常黑膽質型哮喘患者血漿中α-葡萄糖、β-葡萄糖、糖蛋白明顯升高(P <0.05),丙氨痠、穀氨痠、纈氨痠、亮氨痠、異亮氨痠、甘氨痠、酪氨痠、苯丙氨痠、1-甲基組氨痠等多種氨基痠含量升高,乙酰乙痠、丙酮,丙酮痠、乳痠、肌痠、肌痠酐、肉堿等代謝物含量升高,LDL 和 VLDL、不飽和脂類、乙痠、乙酰半胱氨痠、穀氨酰胺、鯊肌醇等化閤物含量升高(P <0.05)。結論異常黑膽質型哮喘患者體內能量代謝和蛋白質代謝髮生改變,體內糖異生和免疫功能的紊亂程度較嚴重,這可能是異常黑膽質型哮喘形成的生物學基礎之一,也從一箇側麵證實維醫“同病異證”的科學性。
목적:게시지기관효천환자이상흑담질형여비이상흑담질형적혈장대사조변화정황급발생궤제。방법대61례이상흑담질형지기관효천환자화55명비이상흑담질형지기관효천환자적혈장진행핵자공진경보검측,통과보도분단적분후운용정교편최소이승판별분석법(OPLS-DA)분석소채집적도보。결과이상흑담질형효천환자여건강대조조상비,혈장중이량안산、량안산、병안산、힐안산、락안산、감안산등안기산이급곡안선알、α-포도당、β-포도당、당단백、기산、유산、육감、병동、병동산、지류[포함저밀도지단백(LDL)화겁저밀도지단백(VLDL)]、불포화지류적함량균유불동정도적강저(P <0.05)。여비이상흑담질형효천환자상비,이상흑담질형효천환자혈장중α-포도당、β-포도당、당단백명현승고(P <0.05),병안산、곡안산、힐안산、량안산、이량안산、감안산、락안산、분병안산、1-갑기조안산등다충안기산함량승고,을선을산、병동,병동산、유산、기산、기산항、육감등대사물함량승고,LDL 화 VLDL、불포화지류、을산、을선반광안산、곡안선알、사기순등화합물함량승고(P <0.05)。결론이상흑담질형효천환자체내능량대사화단백질대사발생개변,체내당이생화면역공능적문란정도교엄중,저가능시이상흑담질형효천형성적생물학기출지일,야종일개측면증실유의“동병이증”적과학성。
Objective To explore the metabolic variation and pathogenesis of bronchial asthma of Abnormal Savda syndrome and Abnormal unsavda syndrome in Traditional Uyghur Medicine (TCM).Methods Ser-um samples from 61 cases of Abnormal Savda syndrome bronchial asthma patients and 55 cases of Abnor-mal unsavda syndrome bronchial asthma patients are detected and described with 1 H-NMR based metabo-nomics,and than the data is analyzed by Orthogonal Partial Least Squares-Discriminant Analysis (OPLS-DA).Results Comparing with the healthy people,the various kinds of amino acids of abnormal savda syndrome bronchial asthma patients are markedly lower,including isoleucine,leucine,alanine,valine, tyrosine,glycine (P <0.05).Glutamine,glucose,glycoprotein,creatine,lactic acid,carnitine,acetone, pyruvic acid,lipid (include LDL and VLDL),unsaturated lipid are also markedly lower comparing with the health people (P <0.05).The another results show that the abnormal savda syndrome bronchial asth-ma patients have a higher degree of glucose,glycoprotein,lactamine,glutamic acid,valine,leucine,iso-leucine,glycine,tyrosine,phenylalanine,1-methylhistidine (P <0.05)and a higher degree of acetoace-tate,acetone,pyruvic acid,lactate,creatine,creatinine,carnitine (P <0.05);another metabolites like lipid(include LDL and VLDL),unsaturated lipid ,acetic acid,acetylcysteine,glutamine,scyllitol in plasma more than the unsavda syndrome bronchial asthma patients (P < 0.05).Conclusion Bronchial asthma patients of the abnormal savda syndrome had transformed in energy metabolism and protein metab-olism.It indicates that the abnormal gluconeogenesis and immunologic function disorder was more severe in bronchial asthma patients of the abnormal savda syndrome than in bronchial asthma patients of the unsavda syndrome.This may be one of the biological foundation from Abnormal Savda syndrome bronchial asthma forma-tion,also confirm the scientific basis of different syndromes in the same disease of Uygur Medicine.