CAJ | 학술논문

目的：探讨新疆维、汉民族宫颈鳞癌及宫颈鳞状上皮内瘤变（CIN）患者的宫颈病变组织中芳香化酶P450（P450arom）和雌激素β受体（ER-β）的表达，了解 P450arom 和 ER-β在宫颈鳞癌及其癌前病变发生发展中的作用，以及其在维、汉族患者中的表达是否存在差异。方法收集宫颈鳞癌组、CIN 组及对照组的石蜡标本180例，3组标本各60例，其中每组标本维、汉民族各30例。采用免疫组化的方法研究 P450arom 及 ER-β在不同宫颈病变组织中的表达，以及其在维、汉族患者中的表达是否存在差异。结果 P450arom 在对照组中的阳性表达率（17．9％）低于宫颈鳞癌组（55．0％）及 CIN 组（48．0％），差异有统计学意义（P ＝0．001）；ER-β在对照组的阳性表达率57．9％，CIN 组为37．3％，宫颈鳞癌组为15．3％，随着宫颈病变程度的增加，其表达呈递减的趋势，差异有统计学意义（P ＝0．000），但 P450arom 及 ER-β在维、汉族患者中的表达差异无统计学意义。结论：宫颈局部组织中的P450arom 表达增高和 ER-β表达降低，可能在促进宫颈鳞癌发生发展的过程中起到作用，但其在维、汉族患者中表达无差异。
목적：탐토신강유、한민족궁경린암급궁경린상상피내류변（CIN）환자적궁경병변조직중방향화매P450（P450arom）화자격소β수체（ER-β）적표체，료해 P450arom 화 ER-β재궁경린암급기암전병변발생발전중적작용，이급기재유、한족환자중적표체시부존재차이。방법수집궁경린암조、CIN 조급대조조적석사표본180례，3조표본각60례，기중매조표본유、한민족각30례。채용면역조화적방법연구 P450arom 급 ER-β재불동궁경병변조직중적표체，이급기재유、한족환자중적표체시부존재차이。결과 P450arom 재대조조중적양성표체솔（17．9％）저우궁경린암조（55．0％）급 CIN 조（48．0％），차이유통계학의의（P ＝0．001）；ER-β재대조조적양성표체솔57．9％，CIN 조위37．3％，궁경린암조위15．3％，수착궁경병변정도적증가，기표체정체감적추세，차이유통계학의의（P ＝0．000），단 P450arom 급 ER-β재유、한족환자중적표체차이무통계학의의。결론：궁경국부조직중적P450arom 표체증고화 ER-β표체강저，가능재촉진궁경린암발생발전적과정중기도작용，단기재유、한족환자중표체무차이。
Objective To explore the expression of P450arom and ER-βwas in squamous cervical cancer and cervical intraepithelial neoplasia in Xinjiang Uygur and Han patients and to investigate their roles in the de-velopment of squamous cervical cancer (SCC)and cervical intraepithelial neoplasia (CIN).Methods The expressions of P450arom and ER-βin 60 SCC specimens,60 CIN specimens and 60 adjacent normal cervical tissues were examined and explored by immunohistochemical method (S-P)to find the differences in the different grades of cervical lesions and differences in their expressions between Uygur and Han patients. Results The expression of P450arom in normal cervical tissues (17.9%)was lower than that in CIN (48%)and SCC (55%),with significantly statistical difference (P =0.001);the expression of ER-βwas 57.9% in normal cervical tissue,while 37.3% in CIN and 15.3% in SCC;with histologic grading in cervical lesions increasing,the expression of ER-βwas decreasing (P =0.000);there were no differences in the ex-pression of P450arom and ER-β between Uyghur and Han ethnic groups.Conclusion The increasing ex-pression of P450arom and the decreasing expression of ER-β in cervical local tissue may lead to promoting squamous carcinogenesis but there were no differences in their expressions between Uyghur and Han patients.