临床荟萃
臨床薈萃
림상회췌
CLINICAL FOCUS
2014年
11期
1201-1206
,共6页
余志敏%王智泉%张光宇%吴晓燕
餘誌敏%王智泉%張光宇%吳曉燕
여지민%왕지천%장광우%오효연
冠心病%心绞痛%心肌梗死%ABO 血型系统%Meta 分析
冠心病%心絞痛%心肌梗死%ABO 血型繫統%Meta 分析
관심병%심교통%심기경사%ABO 혈형계통%Meta 분석
coronary disease%angina pectoris%myocardial infarction%ABO blood-group system%meta-analysis
目的：系统评价冠心病与 ABO 血型分布的关系。方法计算机检索 Cochrane Library、PubMed、万方数据库、中国学术期刊数据库(CNKI)、中国生物医学文献数据库(CBM)至2014年1月31日,收集冠心病与 ABO 血型关系的病例对照研究及队列研究,按纳入和排除标准由2名评价者独立选择试验、提取资料,交叉核对并进行方法学质量评估后,使用 RevMan 5.2软件进行 Meta 分析。结果纳入17项研究,冠心病患者15988例。Meta 分析结果显示：①与对照组比较,冠心病患者中 A 血型的比例升高(OR =1.27,95% CI =1.09~1.48,P <0.01),O 血型的比例降低(OR =0.79,95% CI =0.68~0.91,P <0.01),B 血型(OR =1.04,95% CI =0.93~1.16,P >0.05)与AB 血型(OR =0.88,95% CI =0.70~1.09,P >0.05)比较差异无统计学意义；②与对照组比较,心肌梗死(MI)组O 血型的比例降低(OR =0.63,95% CI =0.45~0.86,P <0.01)。两组 A、B、AB 血型 MI 分布比较差异无统计学意义。结论 A 血型人群患冠心病的风险增加,而 O 血型则为冠心病与 MI 发病的保护因子。B 血型及 AB 血型与冠心病及 MI 的发病均无明显相关性。
目的：繫統評價冠心病與 ABO 血型分佈的關繫。方法計算機檢索 Cochrane Library、PubMed、萬方數據庫、中國學術期刊數據庫(CNKI)、中國生物醫學文獻數據庫(CBM)至2014年1月31日,收集冠心病與 ABO 血型關繫的病例對照研究及隊列研究,按納入和排除標準由2名評價者獨立選擇試驗、提取資料,交扠覈對併進行方法學質量評估後,使用 RevMan 5.2軟件進行 Meta 分析。結果納入17項研究,冠心病患者15988例。Meta 分析結果顯示：①與對照組比較,冠心病患者中 A 血型的比例升高(OR =1.27,95% CI =1.09~1.48,P <0.01),O 血型的比例降低(OR =0.79,95% CI =0.68~0.91,P <0.01),B 血型(OR =1.04,95% CI =0.93~1.16,P >0.05)與AB 血型(OR =0.88,95% CI =0.70~1.09,P >0.05)比較差異無統計學意義；②與對照組比較,心肌梗死(MI)組O 血型的比例降低(OR =0.63,95% CI =0.45~0.86,P <0.01)。兩組 A、B、AB 血型 MI 分佈比較差異無統計學意義。結論 A 血型人群患冠心病的風險增加,而 O 血型則為冠心病與 MI 髮病的保護因子。B 血型及 AB 血型與冠心病及 MI 的髮病均無明顯相關性。
목적：계통평개관심병여 ABO 혈형분포적관계。방법계산궤검색 Cochrane Library、PubMed、만방수거고、중국학술기간수거고(CNKI)、중국생물의학문헌수거고(CBM)지2014년1월31일,수집관심병여 ABO 혈형관계적병례대조연구급대렬연구,안납입화배제표준유2명평개자독립선택시험、제취자료,교차핵대병진행방법학질량평고후,사용 RevMan 5.2연건진행 Meta 분석。결과납입17항연구,관심병환자15988례。Meta 분석결과현시：①여대조조비교,관심병환자중 A 혈형적비례승고(OR =1.27,95% CI =1.09~1.48,P <0.01),O 혈형적비례강저(OR =0.79,95% CI =0.68~0.91,P <0.01),B 혈형(OR =1.04,95% CI =0.93~1.16,P >0.05)여AB 혈형(OR =0.88,95% CI =0.70~1.09,P >0.05)비교차이무통계학의의；②여대조조비교,심기경사(MI)조O 혈형적비례강저(OR =0.63,95% CI =0.45~0.86,P <0.01)。량조 A、B、AB 혈형 MI 분포비교차이무통계학의의。결론 A 혈형인군환관심병적풍험증가,이 O 혈형칙위관심병여 MI 발병적보호인자。B 혈형급 AB 혈형여관심병급 MI 적발병균무명현상관성。
Objective To objectively evaluate the correlation between coronary heart disease(CHD)and ABO blood groups.Methods Such databases as Cochrane Library,PubMed,Wanfang,CNKI,and CBM were searched from their establishment to January 31,2014 for collecting the case-control study and cohort study about CHD and ABO blood group systems. After study selection,assessment and data extraction were conducted by two reviewers independently,meta-analysis was performed using the RevMan 5.2 software and Stata 12.0 software.Results Seventeen studies involving 1 5 988 patients were included.The results of meta-analysis showed that:① compared with controls,CHD patients had higher proportion in blood group A(OR = 1.27,95% CI = 1.09-1.48,P <0.01 ),less proportion in group O(OR =0.79,95% CI =0.68-0.91,P <0.01),and the CHD proportion showed no significant difference between blood group B(OR =1.04,95% CI =0.93-1.1 6,P >0.05)and AB(OR =0.88,95% CI =0.70-1.09,P >0.05);②compared with healthy controls,myocardial infarction(MI)patients had less proportion in group O (OR =0.63,95% CI =0.45-0.86,P <0.01),and the MI proportion showed no significant difference among group A,group B and AB.Conclusion Blood group A population has a higher risk for CHD,whereas group O was a protective factor for CHD and MI,there were no significant association between group B/AB and CHD/MI.
