CAJ | 학술논문

以海藻酸钠(SA)和酸化凹凸棒石(H+-ATP)为原料，运用溶液共混法制备了一种具有优良缓释性能的复合材料，并以其为基质材料制备了双氯芬酸钠(DS)缓释片。利用SEM、FTIR和XRD对复合材料形貌和结构进行了表征，考察了酸改性剂浓度、H+-ATP用量和复合时间对复合材料缓释性能的影响，以获得最佳复合工艺。结果表明，当用12 mol·L-1盐酸酸化的ATP量占复合物总量60%时，复合缓释片在体外模拟肠液中缓释性能最佳。与单一海藻酸缓释片相比，复合缓释片2 h的累积释放率由42.6%下降到23.7%，有效改善了“突释”效应。释放动力学研究表明，复合缓释片的释药行为可以用Ritger-Peppas方程很好地拟合，释药速率受骨架溶蚀和药物扩散双重控制。H+-ATP的加入显著改善了海藻酸的缓释性能。
이해조산납(SA)화산화요철봉석(H+-ATP)위원료，운용용액공혼법제비료일충구유우량완석성능적복합재료，병이기위기질재료제비료쌍록분산납(DS)완석편。이용SEM、FTIR화XRD대복합재료형모화결구진행료표정，고찰료산개성제농도、H+-ATP용량화복합시간대복합재료완석성능적영향，이획득최가복합공예。결과표명，당용12 mol·L-1염산산화적ATP량점복합물총량60%시，복합완석편재체외모의장액중완석성능최가。여단일해조산완석편상비，복합완석편2 h적루적석방솔유42.6%하강도23.7%，유효개선료“돌석”효응。석방동역학연구표명，복합완석편적석약행위가이용Ritger-Peppas방정흔호지의합，석약속솔수골가용식화약물확산쌍중공제。H+-ATP적가입현저개선료해조산적완석성능。
A composite material with improved sustained release properties, based on hybridization of sodium alginate (SA) and acidified-attapulgite (H+-ATP ), was prepared by solution mixing and was developed for drug carrier. Diclofenac sodium (DS) was selected as the model drug to obtain release data from the composite-based matrix tablets in phosphate buffer solution (PBS)in vitro. The morphology and structure of the composite were characterized by FTIR, SEM and XRD. The effect of content of acid modifier, H+-ATP content and mixing time on the slow release properties of the composite were investigated to obtain optimum process condition. The composite with 60% H+-ATP treated by 12 mol·L-1 HCl exhibited perfect release properties. Compared with pure alginate tablets, the burst release of 42.6 % in 2 h decreased to 23.7% for the prepared composite. The drug release process of the composite was better fitted by the Ritger-Peppas model and the rate of drug release was governed by both diffusion and swelling mode. The introduced H+-ATP improved the release properties of alginate significantly.