CAJ | 학술논문

目的：探讨贝前列素钠联合大株红景天治疗腔隙性脑梗死的临床疗效。方法将120例腔隙性脑梗死患者随机分为治疗组和对照组，每组各60例，治疗组给予贝前列素钠联合大株红景天口服，对照组给予阿司匹林肠溶片、尼莫地平、辛伐他汀口服，2组其他治疗药物相同，2周后观察临床症状改善程度、血液流变学、血脂和椎基底动脉血流情况。结果2组总有效率比较差异无统计学意义（P＞0．05），2组疗效相当。2组均能改善血黏度，降低血脂，改善椎基底动脉血流（P＜0．05），但是治疗组在血液流变学和椎基底动脉血流改善方面优于对照组（P＜0．05），血脂变化与对照组比较差异无统计学意义（P＞0．05）。结论贝前列素钠联合大株红景天口服适于腔隙性脑梗死的治疗。
목적：탐토패전렬소납연합대주홍경천치료강극성뇌경사적림상료효。방법장120례강극성뇌경사환자수궤분위치료조화대조조，매조각60례，치료조급여패전렬소납연합대주홍경천구복，대조조급여아사필림장용편、니막지평、신벌타정구복，2조기타치료약물상동，2주후관찰림상증상개선정도、혈액류변학、혈지화추기저동맥혈류정황。결과2조총유효솔비교차이무통계학의의（P＞0．05），2조료효상당。2조균능개선혈점도，강저혈지，개선추기저동맥혈류（P＜0．05），단시치료조재혈액류변학화추기저동맥혈류개선방면우우대조조（P＜0．05），혈지변화여대조조비교차이무통계학의의（P＞0．05）。결론패전렬소납연합대주홍경천구복괄우강극성뇌경사적치료。
Objective To investigate the effect of Beraprost Sodium combined with large plant rhodiola on lacunar infarction.Methods 120 patients with lacunar infarction were randomly divided into two groups.Patients in two groups were treated by basic treatment.60 cases in treatment group received Beraprost Sodium combined with large plant rhodiola.60 cases in control group received Aspirin enteric-coated metformin hydrochloride, nim horizon and simvastatin treatment.After treatment of 14 days the curative effect were observed.The degree of nerve defect was observed in two groups before and after treatment.Blood rheology and blood lipid changes were measured.The changes of vertebrobasilar artery velocity were observed before and after treatment.Results There was no significant difference between two groups on the total effective rate (P>0.05).These were therapeutic equivalence.Hemorheo-logical index, lipid levels and vertebral -basilar artery mean flow velocity after treatment were improved as com-pared with those before treatment in two groups (P<0.05).The improvement intreatment group was superior to that in control group (P<0.05).Conclusion Beraprost Sodium combined with large plant rhodiola can improve clinical symptoms of patients with lacunar cerebral infarction, reduce blood fat and blood viscosity, increase the vertebral -basilar artery blood flow, the curative effect is distinct.