CAJ | 학술논문

目的：观察滋阴润燥生津汤治疗干燥综合征（ SS）前后人体免疫球蛋白（ Ig） A、IgG及IgM 的变化，分析其对机体免疫功能的调节作用。方法将112例SS患者随机分为2组，治疗组56例予滋阴润燥生津汤口服加雾化吸入治疗，对照组56例予硫酸羟氯喹片治疗。治疗2个月后检测免疫球蛋白指标变化情况，统计临床疗效。结果治疗组总有效率92．86％，对照组总有效率71．43％，2组比较差异有统计学意义（P＜0．05），治疗组疗效优于对照组。治疗组治疗后免疫球蛋白指标较本组治疗前均明显改善（P＜0．05），而对照组变化无统计学意义（P＞0．05）；2组治疗后免疫球蛋白指标比较差异有统计学意义（P＜0．05），治疗组改善情况优于对照组。结论滋阴润燥生津汤可有效地调节SS患者机体的免疫功能。
목적：관찰자음윤조생진탕치료간조종합정（ SS）전후인체면역구단백（ Ig） A、IgG급IgM 적변화，분석기대궤체면역공능적조절작용。방법장112례SS환자수궤분위2조，치료조56례여자음윤조생진탕구복가무화흡입치료，대조조56례여류산간록규편치료。치료2개월후검측면역구단백지표변화정황，통계림상료효。결과치료조총유효솔92．86％，대조조총유효솔71．43％，2조비교차이유통계학의의（P＜0．05），치료조료효우우대조조。치료조치료후면역구단백지표교본조치료전균명현개선（P＜0．05），이대조조변화무통계학의의（P＞0．05）；2조치료후면역구단백지표비교차이유통계학의의（P＜0．05），치료조개선정황우우대조조。결론자음윤조생진탕가유효지조절SS환자궤체적면역공능。
Objective To observe the effect of Ziyin Runzao shengjin decoction on IgA, IgG and IgM of Sjogren syndrome ( SS) .Methods 112 patients with SS were randomly divided into two groups.56 cases in treat-ment group were treated by Ziyin Runzao shengjin decoction combined with inhalation therapy.56 patients in control group were given hydroxychloroquine sulfate tablets.( Immunoglobulin indicators ) changes were observed.Results The total effective rate in treatment group(92.86%) was superior to that in control group (71.43%,P<0.05) .Im-munoglobulin indicators after treatment were sisnificantly improved as conpared with those before treatment in treat-ment group (P<0.05).There were sisnifi cant difference between two groups on the immuanoslobulin indicators after treatment (P<0.05).The improvements of immanoslobulin indicators in treatment group were superior to those in control group after treatment (P<0.05).Conclusion Ziyin Runzao shengjin decoction can effectively relieve the main symptoms in patients with SS and improved correlation detection indicators, with better clinical efficacy.