CAJ | 학술논문

MicroRNAs (miRNAs)作为重要的基因表达调节因子广泛参与发育、凋亡、肿瘤、免疫和机体-微生物相互作用等生理病理过程.miRNAs可对宿主固有免疫和适应性免疫进行精细调控.目前几种常见致病菌(幽门螺旋杆菌、沙门氏菌、李斯特氏菌、分枝杆菌)感染中宿主miRNAs调节免疫应答的相关研究表明,miRNAs在调节宿主抗细菌感染免疫应答中发挥重要作用.明确机体抗感染免疫中miRNAs如何调节免疫应答将有助于开发作用于miRNAs或其靶标的新的治疗手段.
MicroRNAs (miRNAs)작위중요적기인표체조절인자엄범삼여발육、조망、종류、면역화궤체-미생물상호작용등생리병리과정.miRNAs가대숙주고유면역화괄응성면역진행정세조공.목전궤충상견치병균(유문라선간균、사문씨균、리사특씨균、분지간균)감염중숙주miRNAs조절면역응답적상관연구표명,miRNAs재조절숙주항세균감염면역응답중발휘중요작용.명학궤체항감염면역중miRNAs여하조절면역응답장유조우개발작용우miRNAs혹기파표적신적치료수단.
microRNAs (miRNAs) are implicated as important regulators of various physiological as well as pathological processes,including development,apoptosis,cancer,immunity,and host-microorganism interactions.miRNAs can implement a quantitative regulation to innate and acquired immune responses.The current studies on the regulation of host miRNAs in response to infections caused by common bacterial pathogens (Helicobacter pylori,Salmonella enterica,Listeria monocytogenes and Mycobacterium) illustrate that miRNAs play critical roles in modulating immune responses against bacterial infection.Understanding how the immune response is regulated by miRNAs during infection will facilitate the development of novel therapeutic approaches against pathogenic bacteria.