CAJ | 학술논문

目的：评价榄香烯口服乳联合顺铂、氟尿嘧啶治疗晚期食道癌的临床疗效及不良反应。方法将128例晚期食道癌患者随机分为观察组和对照组，各64例。对照组采用顺铂、亚叶酸钙、氟尿嘧啶等进行治疗，观察组在对照组用药基础上加服榄香烯口服乳，21 d为1个周期。治疗2个周期后按 RESIST 标准评价疗效，并比较两组患者的不良反应及生活质量情况。结果观察组1年生存率为56.25%，明显高于对照组的45.31%（ P<0.05）；治疗2个周期后，观察组总有效率为39.06%，明显高于对照组的29.69%（ P<0.05）；两组患者骨髓抑制及消化道不良反应发生率相似；观察组Karnofsky ( KPS )评分提高者为32.81%，明显高于对照组的29.69%（ P<0.05）。观察组治疗后CEA，CA199，CA724水平明显低于对照组（ P<0.05）。结论榄香烯乳联合顺铂、氟尿嘧啶能显著提高晚期食道癌患者的疗效和生活质量，且不增加不良反应，值得临床推广。
목적：평개람향희구복유연합순박、불뇨밀정치료만기식도암적림상료효급불량반응。방법장128례만기식도암환자수궤분위관찰조화대조조，각64례。대조조채용순박、아협산개、불뇨밀정등진행치료，관찰조재대조조용약기출상가복람향희구복유，21 d위1개주기。치료2개주기후안 RESIST 표준평개료효，병비교량조환자적불량반응급생활질량정황。결과관찰조1년생존솔위56.25%，명현고우대조조적45.31%（ P<0.05）；치료2개주기후，관찰조총유효솔위39.06%，명현고우대조조적29.69%（ P<0.05）；량조환자골수억제급소화도불량반응발생솔상사；관찰조Karnofsky ( KPS )평분제고자위32.81%，명현고우대조조적29.69%（ P<0.05）。관찰조치료후CEA，CA199，CA724수평명현저우대조조（ P<0.05）。결론람향희유연합순박、불뇨밀정능현저제고만기식도암환자적료효화생활질량，차불증가불량반응，치득림상추엄。
Objective To evaluate the clinical efficacy and adverse reactions of Elemi Oral Emulsion combined with cisplatin and fluo-rouracil in treating advanced gastric cancer. Methods 128 patients with advanced gastric cancer were randomLy divided into the obser-vation group and the control group,64 cases in each group. The control group adopted the therapy of cisplatin,calcium folinate and flu-orouracil,etc. On the basis of the control group medication,the observation group was added with Elemi Oral Emulsion,with 21 d as 1 treatment cycle. The curative effect after 2-cycle treatment was evaluated according to the RESIST standard. The adverse reactions and the quality of life were compared between the two groups. Results The 1-year survival rate in the observation group was 56. 25%, which was significantly higher than 45. 31% in the control group( P < 0. 05);the total effective rate after 2-cycle treatment in the observation group was 39. 06%,which was significantly higher than 29. 69% in the control group( P < 0. 05);the occurrence rate of myelosuppression and the digestive tract adverse reactions in the two group was similar;the increase rate of KPS in the observation group was 32. 81%,which was significantly higher than 29. 69% in the control group ( P < 0. 05 ) . The CEA,CA199 and CA724 levels in the observation group were significantly lower than those in the control group( P < 0. 05). Conclusion Elemi Oral Emulsion com-bined with cisplatin and fluorouracil can significantly improve the curative efficacy and the quality of life without increasing adverse re-actions in the patients with advanced gastric cancer,which is worthy of clinical promotion.