CAJ | 학술논문

目的：观察醒脑丸对气虚血瘀血管性痴呆大鼠的治疗作用。方法将气虚造模成功的大鼠随机分为4组，即空白组、模型组、脑复康片组、醒脑丸组。均连续灌胃15 d，每天早晚各1次。观察大鼠行为学指标，测定血浆血栓素B2及大脑皮层一氧化氮（NO）含量；观察大脑海马区病理形态，检测大脑海马促细胞凋亡蛋白Bax表达。结果醒脑丸可降低血浆血栓素B2含量，改善气虚血瘀征象；降低大脑皮层NO含量；对海马CA1区神经元的损伤有明显保护作用；能下调脑缺血后促细胞凋亡蛋白Bax的表达。结论醒脑丸可改善气虚血瘀血管性痴呆大鼠的症状。
목적：관찰성뇌환대기허혈어혈관성치태대서적치료작용。방법장기허조모성공적대서수궤분위4조，즉공백조、모형조、뇌복강편조、성뇌환조。균련속관위15 d，매천조만각1차。관찰대서행위학지표，측정혈장혈전소B2급대뇌피층일양화담（NO）함량；관찰대뇌해마구병리형태，검측대뇌해마촉세포조망단백Bax표체。결과성뇌환가강저혈장혈전소B2함량，개선기허혈어정상；강저대뇌피층NO함량；대해마CA1구신경원적손상유명현보호작용；능하조뇌결혈후촉세포조망단백Bax적표체。결론성뇌환가개선기허혈어혈관성치태대서적증상。
Objective To observe the curative effect of Xingnao Pills on rats with vascular dementia due to qi deficiency and blood sta-sis. Methods The successfully constructed rat models of qi deficiency were randomly divided into 4 groups, i. e., blank group, model group, Naofukang Tablet group and Xingnao Pills group. All groups were performed the intragastric infusion for 15 d, once in the morn-ing and once at the night. The praxiology indexes, plasma thromboxane ( TXB2 ) and NO content in the cerebral cortex were detected, the pathomorphology of brain hippocampus was observed and the expression of pro-apoptotic protein Bax in brain hippocampus were detected. Results Xingnao Pills could decrease the level of TXB2, improved the symptoms of qi deficiency and blood stasis;reduced the NO content in the cerebral cortex; had the obvious protective effect on the injury of neurons in the hippocampus CA1 region; could down-regulated the expression of pro-apoptotic protein Bax. Conclusion Xingnao Pills can improve the symptoms of vascular demen-tia rats due to qi deficiency and blood stasis.