CAJ | 학술논문

目的：探讨NHL患者血清NSE、CA125及β2-MG水平对判断临床疗效和预后的价值。方法：测定46例NHL患者化疗前、后血清NSE、CA125及β2-MG ，分析其与临床疗效和3年生存率的相关性。结果：（1）血清NSE增高患者化疗有效率、3年生存率低于血清 NSE正常患者，差异有统计学意义（P＜0．05）；其中化疗有效患者化疗后血清NSE水平较化疗前明显降低，差异有统计学意义（P＜0．05）。（2）血清CA125增高患者化疗有效率、3年生存率低于血清CA125正常患者，差异有统计学意义（P＜0．05）；化疗有效患者化疗后血清CA125水平较化疗前明显降低，差异有统计学意义（P＜0．05）。（3）血清β2-MG增高患者化疗有效率低于血清β2-MG正常患者，差异有统计学意义（P＜0．05）；血清β2-MG增高患者与正常患者3年生存率比较，差异无统计学意义（P＞0.05）；化疗有效患者化疗后血清β2-MG水平较化疗前明显降低，差异有统计学意义（P＜0．05）。结论：NHL患者血清NSE、CA125及β2-MG水平与化疗敏感性及临床预后密切相关，对判断疗效和预后有重要价值。
목적：탐토NHL환자혈청NSE、CA125급β2-MG수평대판단림상료효화예후적개치。방법：측정46례NHL환자화료전、후혈청NSE、CA125급β2-MG ，분석기여림상료효화3년생존솔적상관성。결과：（1）혈청NSE증고환자화료유효솔、3년생존솔저우혈청 NSE정상환자，차이유통계학의의（P＜0．05）；기중화료유효환자화료후혈청NSE수평교화료전명현강저，차이유통계학의의（P＜0．05）。（2）혈청CA125증고환자화료유효솔、3년생존솔저우혈청CA125정상환자，차이유통계학의의（P＜0．05）；화료유효환자화료후혈청CA125수평교화료전명현강저，차이유통계학의의（P＜0．05）。（3）혈청β2-MG증고환자화료유효솔저우혈청β2-MG정상환자，차이유통계학의의（P＜0．05）；혈청β2-MG증고환자여정상환자3년생존솔비교，차이무통계학의의（P＞0.05）；화료유효환자화료후혈청β2-MG수평교화료전명현강저，차이유통계학의의（P＜0．05）。결론：NHL환자혈청NSE、CA125급β2-MG수평여화료민감성급림상예후밀절상관，대판단료효화예후유중요개치。
To research the values of NSE ,CA125 andβ2-MG for judgement of effect and prognosis in non-Hodgkin lymphoma .Methods:The data of 46 patients with NHL were retrospectively analysed ,the relationships be-tween NSE ,CA125 andβ2-MG activities and the effect of treatment as well as prognosis were studied .Results:(1)The chemotherapy efficacy and three-year survival rate of patients with increased NSE were signifecantly lower than that of patients with normal NSE(P<0 .05);the NSE level of patients with positive response was signifecantly lower than that of patients with negative response in group with increased NSE (P<0 .05) .(2)The chemotherapy efficacy and three-year survival rate of patients with increased CA125 were signifecantly lower than that of patients with normal CA125 (P<0 .05);the CA125 level of patients with positive response was signifecantly lower than that of patients with nega-tive response in group with increased CA125(P<0 .05) .(3)The chemotherapy efficacy of patients with increased β2-MG were signifecantly lower than that of patients with normalβ2-MG (P<0 .05);there was no difference in three-year survival rate between patients with increasedβ2-MG and patients with normalβ2-MG ;theβ2-MG level of patients with positive response was signifecantly lower than that of patients with negative response in group with increasedβ2-MG (P<0 .05) .Conclusion:The levels of NSE ,CA125 andβ2-MG are useful for the judgment of severity ,response to treat-ment and prognosis of NHL .