国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
20期
2792-2793,2810
,共3页
人乳头瘤病毒%聚合酶链式反应%反向斑点杂交技术%亚型分布%宫颈病变
人乳頭瘤病毒%聚閤酶鏈式反應%反嚮斑點雜交技術%亞型分佈%宮頸病變
인유두류병독%취합매련식반응%반향반점잡교기술%아형분포%궁경병변
human papillomavirus%polymerase chain reaction%reverse dot-blot%subtype distribution%cervical lesions
目的：了解上海市奉贤区女性宫颈人乳头瘤病毒（HPV）感染状况和基因亚型分布情况，为预防 HPV感染和宫颈癌防治提供可靠的科学依据。方法采用 PCR 联合反向斑点杂交技术，对2011年2月至2013年10月来本院初次进行 HPV 检查的18194例妇女 HPV 检测结果进行分析。结果18194例样本中阳性例数为2986例，总感染率为16．41％，其中21种基因型全部检出，单一 HPV 病毒感染2714例，2种 HPV 病毒感染148例，占总感染例数的4．96％，3种及以上 HPV 病毒感染124例。住院患者阳性率为12．76％，门诊患者阳性率为16．88％。HPV 感染高危型多于低危型，检出数约为低危型的7．5倍。高危型HPV 感染中，以16、52、58型感染最多；低危型 HPV 感染中以81型感染最多，其次为6、11型。结论奉贤区 HPV 流行整体符合亚洲人群分布规律，又有独特的地域特征。感染年龄高峰在51～65岁，高危型感染高于低危型感染，主要为单基因型感染。
目的：瞭解上海市奉賢區女性宮頸人乳頭瘤病毒（HPV）感染狀況和基因亞型分佈情況，為預防 HPV感染和宮頸癌防治提供可靠的科學依據。方法採用 PCR 聯閤反嚮斑點雜交技術，對2011年2月至2013年10月來本院初次進行 HPV 檢查的18194例婦女 HPV 檢測結果進行分析。結果18194例樣本中暘性例數為2986例，總感染率為16．41％，其中21種基因型全部檢齣，單一 HPV 病毒感染2714例，2種 HPV 病毒感染148例，佔總感染例數的4．96％，3種及以上 HPV 病毒感染124例。住院患者暘性率為12．76％，門診患者暘性率為16．88％。HPV 感染高危型多于低危型，檢齣數約為低危型的7．5倍。高危型HPV 感染中，以16、52、58型感染最多；低危型 HPV 感染中以81型感染最多，其次為6、11型。結論奉賢區 HPV 流行整體符閤亞洲人群分佈規律，又有獨特的地域特徵。感染年齡高峰在51～65歲，高危型感染高于低危型感染，主要為單基因型感染。
목적：료해상해시봉현구녀성궁경인유두류병독（HPV）감염상황화기인아형분포정황，위예방 HPV감염화궁경암방치제공가고적과학의거。방법채용 PCR 연합반향반점잡교기술，대2011년2월지2013년10월래본원초차진행 HPV 검사적18194례부녀 HPV 검측결과진행분석。결과18194례양본중양성례수위2986례，총감염솔위16．41％，기중21충기인형전부검출，단일 HPV 병독감염2714례，2충 HPV 병독감염148례，점총감염례수적4．96％，3충급이상 HPV 병독감염124례。주원환자양성솔위12．76％，문진환자양성솔위16．88％。HPV 감염고위형다우저위형，검출수약위저위형적7．5배。고위형HPV 감염중，이16、52、58형감염최다；저위형 HPV 감염중이81형감염최다，기차위6、11형。결론봉현구 HPV 류행정체부합아주인군분포규률，우유독특적지역특정。감염년령고봉재51～65세，고위형감염고우저위형감염，주요위단기인형감염。
Objective To investigate the infection situation and the gene subtype distribution characteristics of human papilloma-virus(HPV)in Fengxian District of Shanghai to provide the reliable scientific basis for preventing HPV infection and the prevention and treatment of cervical cancer.Methods The PCR combined with reverse dot-blot technique was adopted to analyze the HPV de-tection results among 18 194 women in our hospital from February 2011 to October 2013.Results Among 18 194 cases of sample, 2 986 cases were HPV positive with the total HPV infection rate of 16.41%,in which 21 genotypes were all detected out.Single HPV genotype infection was in 2714 cases,two kinds of HPV genotype infection were in 148 cases(4.96%)and three kinds or more of HPV genotype infection were in 124 cases.The HPV positive rate was 16.88% in the outpatient and 12.76% in the inpa-tients.In the HPV infection,the high-risk type was more than the low-risk type,its detection number was 7.5 times of low-risk type.Most of the high-risk HPV infection were HPV16,52,58;most of the low-risk HPV infection was HPV cp8304,followed by HPV6 and HPV11.Conclusion The HPV prevalence in Fengxian District is generally in line with the Asian population distribution rule,but has its own unique regional characteristics.The infection age peak is 51-65 years old.The high-risk type infection is high-er than the low-risk type infection,which is dominated by the single genotype infection.
