CAJ | 학술논문

目的：了解恶性肿瘤患者继发非发酵菌下呼吸道感染的耐药性，为临床合理使用抗菌药物提供依据。方法收集恶性肿瘤患者下呼吸道标本，经全自动微生物鉴定仪鉴定，采用 K-B 法进行药敏试验，按 CLSI 2012标准判定药敏结果，用 WHO-NET 5．6软件分析数据。结果从恶性肿瘤患者下呼吸道标本中共分离非发酵菌172株，其中铜绿假单胞菌最多，占45．9％，其次为鲍曼不动杆菌和嗜麦芽寡养单胞菌，分别占36．0％和10．5％。药敏试验表明，5种非发酵菌对多种抗菌药物均表现为高度耐药或多重耐药。结论非发酵菌多重耐药现象严重，临床应重视非发酵菌感染和耐药性监测，并依据药敏试验结果合理选用抗菌药物，以减少耐药菌株的产生。
목적：료해악성종류환자계발비발효균하호흡도감염적내약성，위림상합리사용항균약물제공의거。방법수집악성종류환자하호흡도표본，경전자동미생물감정의감정，채용 K-B 법진행약민시험，안 CLSI 2012표준판정약민결과，용 WHO-NET 5．6연건분석수거。결과종악성종류환자하호흡도표본중공분리비발효균172주，기중동록가단포균최다，점45．9％，기차위포만불동간균화기맥아과양단포균，분별점36．0％화10．5％。약민시험표명，5충비발효균대다충항균약물균표현위고도내약혹다중내약。결론비발효균다중내약현상엄중，림상응중시비발효균감염화내약성감측，병의거약민시험결과합리선용항균약물，이감소내약균주적산생。
Objective To understand the drug resistance in cancer patients with secondary non-fermenting bacterial lower respir-atory tract infection in order to provide a basis for clinical rational use of antibacterial drugs.Methods The lower respiratory tract specimens were collected from the patients with malignant tumor and identified by the fully automated microbial identification sys-tem,the drug susceptibility test was performed by using K-B method and the drug susceptibility test results were judged according to CLSI 2012 standard.The data were analyzed by the WHONET 5.6 software.Results 172 strains of non-fermenting bacteria were isolated from the lower respiratory tract specimens in the patients with malignant tumors,in which Pseudomonas aeruginosa was maximum,accounted for 45.9%,followed by Acinetobacter baumannii and Stenotrophomonas maltophilia ,accounted for 36. 0% and 10.5 % respectively.The drug susceptibility test showed that five kinds of non-fermenter demonstrated the high resistance or multi-resistance to multiple antibacterial drugs.Conclusion Non-fermenting bacterial multi-drug resistant phenomenon is seri-ous,clinic should pay attention to non-fermenting bacterial infection and drug resistance monitoring,antibacterial drugs should be rationally used according to the drug susceptibility test results in order to reduce the generation of drug-resistant strains.